Effect of Ionizing Radiation on the Differentiation of ROS 17/2.8 Osteoblasts through Free Radicals
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概要
- 論文の詳細を見る
Although the acceleration of bone regeneration by radiation has been reported, the mechanisms of action of radiation on bone are unclear. The present results indicate that ionizing radiation-stimulated differentiation could result from the generation of reactive oxygen species during radiation exposure. The free radical release is considered as the most important mechanism of bone effect by radiation treatment. In addition, we report that radiation induced transient activation of c-Jun N-terminal kinase/ stress-activated protein kinase (JNK/SAPK) activation and the transcription factor, AP-1. The JNK and AP-1 activation is mediated with radiation-released free radicals in ROS 17/2.8 osteoblasts. These results indicate that ionizing radiation at a single dose of up to 5 Gray stimulates differentiation of ROS 17/2.8 osteoblasts via free radial release which may affect JNK/SAPK and AP-1 activities.
- 日本放射線影響学会の論文
著者
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Kim Hyung-Min
Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee
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Hong Seung-heon
Vestibulocochlear Research Center Of Wonkwang University
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Hong S‐h
韓国
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Hong Seung-heon
韓国
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Hong Seung-heon
Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University
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Na Ho-jeong
韓国
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PARK Rae-Kil
VestibuloCochlear Research Center of Wonkwang University
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PARK Rae-Kil
Department of Microbiology and Immunology, VestibuloCochlear Research Center of Wonkwang University
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Kim Hyung-min
韓国
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CHAE HAN-JUNG
Department of Dental Pharmacology, School of Dentistry, Wonkwang University
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CHAE SOO-WAN
Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk Nat
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KANG JANG-SOOK
Department of Dental Pharmacology, School of Dentistry, Wonkwang University
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BANG BYUNG-GWAN
Department of Dental Pharmacology, School of Dentistry, Wonkwang University
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HAN JO-IL
Department of Dental Pharmacology, School of Dentistry, Wonkwang University
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MOON SUN-ROCK
Department of Radiation Oncology
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SO HONG-SEOB
Department of Microbiology and Immunology
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JEE KEUN-SOO
Department of Oriental Pharmacy, School of Pharmacy, Center of Oriental Medicinal Science, Wonkwang
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KIM HYUNG-RYONG
Department of Dental Pharmacology, School of Dentistry, Wonkwang University
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Moon Sun-rock
韓国
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Moon Sun-rock
Department Of Radiation Oncology School Of Pharmacy Center Of Oriental Medicinal Science Wonkwang Un
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Chae Han-jung
Dep. Of Pharmacology And Inst. Of Cardiovascular Res. School Of Medicine Chonbuk National Univ.
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Chae Han-jung
Department Of Dental Pharmacology And Wonkwang Dental Research Institute School Of Dentistry Wonkwan
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Han Jo-il
Department Of Dental Pharmacology School Of Dentistry Wonkwang University
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Han Jo-il
Department Of Dental Pharmacology School Of Dentistry Wonkwan University
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Jung H‐s
Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei
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Kim H‐m
Kyung Hee Univ. Seoul Kor
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Kim Hyung-min
Department Of Pharmacology College Of Oriental Medicine Kyung Hee University
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Chae Soo-wan
Dep. Of Pharmacology And Inst. Of Cardiovascular Res. School Of Medicine Chonbuk National Univ.
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Chae Soo-wan
Department Of Pharmacology And Institute Of Cardiovascular Research School Of Medicine Chonbuk Natio
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Jung Hyuk-sang
Department Of Anatomy College Of Oriental Medicine Kyung Hee University
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Na Ho‐jeong
College Of Pharmacy Wonkwang University
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Kim Hyung‐min
Dep. Of Anatomy School Of Medicine Chonbuk National Univ.
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Kim Hyung-ryong
Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang
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Kim H.
韓国
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Kim H‐m
Yonsei Univ. School Of Medicine
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So Hong-seob
韓国
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Jee Keun-soo
Department Of Oriental Pharmacy School Of Pharmacy Center Of Oriental Medicinal Science Wonkwang Uni
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Jee Keun-soo
Department Of Oriental Pharmacy School Of Pharmacy Center Of Oriental Medicinal Science Wondwang Uni
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Kang Jang-sook
Department Of Dental Pharmacology School Of Dentistry Wonkwang University
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Kang Jang-sook
Department Of Dental Pharmacology School Of Dentistry Wonkwan University
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Jung H‐a
Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.
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Bang Byung-gwan
Department Of Dental Pharmacology School Of Dentistry Wonkwang University
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Bang Byung-gwan
Department Of Dental Pharmacology School Of Dentistry Wonkwan University
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Kim Hong‐joon
Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu
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Shin H‐y
Kyung Hee Univ. Seoul Kor
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Kim Hyung-Ryong
Department of Dental Pharmacology and Wonkwang Biomaterial Implant Research Institute, School of Dentistry, Wonkwang University
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