Sargassum hemiphyllum Inhibits Atopic Allergic Reaction via the Regulation of Inflammatory Mediators

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概要

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• Sargassum hemiphyllum (SH) has long been used in Korean folk medicine for the therapeutic treatment of various allergic diseases. The effects of SH in previous experimental models, however, have been inconclusive. We studied the effects of methanol extract of SH on mast cells. Our experiments showed that SH significantly inhibited compound 48/80-induced histamine and β-hexosaminidase release from rat peritoneal mast cells. SH inhibited interleukin (IL)-8 and tumor necrosis factor (TNF)-α release induced by phorbol 12-myristate 13-acetate and A23187 from HMC-1, and it also showed an inhibitory effect on the anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction. In addition, SH inhibited the increase of TNF-α-induced NF-κB protein levels, transcription factor of TNF-α from 293T cells. A period of 48 h exposure to SH had little effect on HMC-1 cell viability. Our results suggest that SH has an inhibitory effect on the atopic allergic reaction and thus this may be useful in the treatment of allergic inflammatory diseases, such as atopic dermatitis.

• 社団法人 日本薬理学会の論文
• 2005-02-20

著者

• Jung Hyuk-sang

  Biochip Research Center Hoseo University

• Kim Hyung-min

  College Of Oriental Medicine Kyung Hee University

• Jeong Hyun-ja

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Hong Seung-Heon

  College of Pharmacy, VCRC of Wonkwang University

• Moon Phil-dong

  College Of Oriental Medicine Kyung Hee University

• Moon Phil-dong

  College Of Pharmacy Wonkwang University

• Hong Seung-heon

  Vestibulocochlear Research Center Of Wonkwang University

• Hong S‐h

  韓国

• Hong Seung-heon

  韓国

• Hong Seung-heon

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Na Ho-jeong

  韓国

• NA Ho-Jeong

  College of Pharmacy, Woosuk University

• Kim Hyung-min

  韓国

• KO Seong-Gum

  College of Oriental Pharmacy, Wonkwang University

• LEE Hee-Jung

  Division of Ocean Science, Korea Maritime University

• JUNG Hyun-Ah

  Division of Ocean Science, Korea Maritime University

• SEO Youngwan

  Division of Ocean Science, Korea Maritime University

• OH Jay-Min

  Department of Anatomy, School of Medicine, Wonkwang University

• LEE Bong-Ho

  Department of Applied Chemistry, Hanbat National University

• CHOI Byoung-Wook

  Department of Applied Chemistry, Hanbat National University

• Park S‐g

  Dep. Of Prescriptionology Coll. Of Oriental Medicine Kyung Hee Univ.

• Jung H‐s

  Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei

• Kim H‐m

  Kyung Hee Univ. Seoul Kor

• Kim Hyung

  College Of Oriental Medicine Kyung Hee University

• Lee Hong-beom

  Division Of Ocean Science Korea Maritime University

• Soh Yunjo

  Dep. Of Dental Pharmacology School Of Dentistry Chonbuk National Univ.

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Na Ho‐jeong

  College Of Pharmacy Wonkwang University

• Kim Hyung‐min

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim Hyung-ryong

  Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang

• Kim H.

  韓国

• Kim H‐m

  Yonsei Univ. School Of Medicine

• Lee B‐h

  Department Of Applied Chemistry Hanbat National University

• Lee Hyo-jung

  Coll. Of Oriental Medicine Kyung Hee Univ.

• Lee Bong-ho

  Department Of Applied Chemistry Hanbat National University

• Na Ho‐jeong

  韓国

• Oh Jay-min

  Department Of Anatomy School Of Medicine Wonkwang University

• So Hong-seob

  韓国

• Soh Yunjo

  Graduate School Of East-west Medical Science Kyung Hee University

• Choi Byoung-wook

  Department Of Applied Chemistry Hanbat National University

• Jung H‐a

  Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.

• Na Ho‐jeong

  Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.

• Kim Hong‐joon

  Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu

• Seo Youngwan

  Division Of Ocean Science Korea Maritime University

• Seo Youngwan

  Division Of Marine Environment And Bioscience Korea Maritime University

• Shin H‐y

  Kyung Hee Univ. Seoul Kor

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