The Effects of BR003 on Memory and Cell Proliferation in the Dentate Gyrus of Rat Hippocampus(Pharmacology)

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概要

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• BR003 is a multi-herbal formula that contains twelve medicinal herbs. We investigated the effects of oral administration of BR003 to Wistar rats on (a) learning and memory using a passive avoidance test and (b) cell proliferation in the dentate gyrus (DG) of the hippocampus using immunohistochemical analysis of 5-bromo-2-deoxyuridine (BrdU) expression. In the passive avoidance test, the retention time of the BR003-treated group was significantly longer than that of the control group (182.64±39.88 vs. 73.08±29.30 s, respectively; n=11; p<0.05). There were significantly more BrdU-immunoreactive cells in the DG in the BR003-treated group than in the control group (1281.07±151.16 vs. 818.01±132.98 cells per DG, respectively; n=11; p<0.05). These results suggest that the administration of BR003 not only improves learning and memory but also increases cell proliferation in the DG of the rat hippocampus.

• 公益社団法人日本薬学会の論文
• 2006-04-01

著者

• Kim Hyung-min

  College Of Oriental Medicine Kyung Hee University

• Oh Myung

  College of Pharmacy, Kyung Hee University

• PARK Wan-Su

  College of Pharmacy, Kyung-Hee University

• Bae Hyunsu

  College Of Oriental Medicine Kyung Hee University

• PARK Seong

  College of Oriental Medicine, Kyung Hee University

• Oh Myung

  College Of Oriental Medicine Kyung Hee University

• Park Wan-su

  College Of Oriental Medicine Kyung Hee University

• PARK Chan

  College of Medicine, Kyung Hee University

• HUH Youngbuhm

  College of Medicine, Kyung Hee University

• KIM Hong-Yeoul

  Institute of Oriental Medicine, Kyung Hee University

• KIM Hocheol

  College of Oriental Medicine, Kyung Hee University

• AHN Duk

  Jaseng Research Institute of Bio-technology and Bioscience

• Huh Youngbuhm

  College Of Medicine Kyung Hee University

• Kim Hong-yeoul

  Institute Of Oriental Medicine Kyung Hee University

• Park Seong

  College Of Oriental Medicine Kyung Hee University

• Park Chan

  College Of Medicine Kyung Hee University

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