Rubus croceacanthus Leveille Inhibits Mast Cell-Mediated Anaphylactic-Like Reaction and Tumor Necrosis Factor-α Secretion(Pharmacology)

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概要

• 論文の詳細を見る

• This work aims at examining the effect of the concentrated methanol extract of Rubus croceacanthus Leveille (RCL) on mast cell-mediated anaphylactic-like reaction in a murine model. RCL inhibited compound 48/80-induced systemic anaphylactic-like reaction. When RCL was given as pre-treatment at concentrations ranging from 0.01 to 1 mg/ml, the histamine release from rat peritoneal mast cells induced by compound 48/80 or antidinitrophenyl (DNP) immunoglobulin E (IgE) was reduced in a dose-dependent manner. RCL also inhibited passive cutaneous anaphylaxis activated by anti-DNP IgE. In addition, RCL inhibited phorbol 12-myristate 13-acetate and A23187-induced tumor necrosis factor-α secretion from human mast cell line HMC-1 cells. These results indicate that RCL may possess a strong anti-anaphylactic activity.

• 社団法人日本薬学会の論文
• 2004-09-01

著者

• Jung Hyuk-sang

  Biochip Research Center Hoseo University

• Kim Hyung-min

  College Of Oriental Medicine Kyung Hee University

• Jeong Hyun-ja

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• KIM Cheorl-Ho

  Department of Biological Science, Sungkyunkwan University and National Research Laboratory for Glyco

• Moon Phil-dong

  College Of Oriental Medicine Kyung Hee University

• Moon Phil-dong

  College Of Pharmacy Wonkwang University

• Kim You-ah

  Div. Of Marine Environment & Bioscience Korea Maritime Univ.

• Hong Seung-heon

  Vestibulocochlear Research Center Of Wonkwang University

• Hong S‐h

  韓国

• Hong Seung-heon

  韓国

• Hong Seung-heon

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Na Ho-jeong

  韓国

• CHOI In-Young

  VestibuloCochlear Research Center of Wonkwang University

• JEONG Hyun-Ja

  College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University

• NA Ho-Jeong

  College of Pharmacy, Woosuk University

• Kim Hyung-min

  韓国

• KIM HYUNG-RYONG

  Department of Dental Pharmacology, School of Dentistry, Wonkwang University

• Kim Yun-kyung

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Kim You-ah

  韓国

• Kim Y‐k

  Wonkwang Univ. Jeonbuk Kor

• MOON Phil-Dong

  Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University

• CHOI In-Young

  Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University

• PARK Seong

  College of Oriental Medicine, Kyung Hee University

• Park S‐g

  Dep. Of Prescriptionology Coll. Of Oriental Medicine Kyung Hee Univ.

• Jung H‐s

  Division In Anatomy And Developmental Biology Department Of Oral Biology College Of Dentistry Yonsei

• Kim H‐m

  Kyung Hee Univ. Seoul Kor

• Kim Hyung

  College Of Oriental Medicine Kyung Hee University

• Jung Hyuk-sang

  Department Of Anatomy College Of Oriental Medicine Kyung Hee University

• Na Ho‐jeong

  College Of Pharmacy Wonkwang University

• Kim Hyung‐min

  Dep. Of Anatomy School Of Medicine Chonbuk National Univ.

• Kim Cheorl-ho

  Department Of Biochemistry And Molecular Biology And Gynecology College Of Oriental Medicine Dongguk

• Kim Cheorl-ho

  Department Of Agricultural Chemistry The University Of Tokyo

• Kim Cheorl-ho

  Laboratory Of Molecular Biology Genetic Engineering Research Institute

• Kim Hyung-ryong

  Dep. Of Dental Pharmacology And Wonkwang Biomaterial Implant Res. Inst. School Of Dentistry Wonkwang

• Kim H.

  韓国

• Kim H‐m

  Yonsei Univ. School Of Medicine

• Na Ho‐jeong

  韓国

• So Hong-seob

  韓国

• Jung H‐a

  Coll. Of Oriental Medicine And Inst. Of Oriental Medicine Kyung Hee Univ.

• Na Ho‐jeong

  Dep. Of Pharmacology Coll. Of Oriental Medicine Inst. Of Oriental Medicine Kyung Hee Univ.

• Kim Yun-kyung

  Department Of Biological Science Sookmyung Women's University

• Kim Hong‐joon

  Department Of Veterinary Medicine College Of Life Sciences Research Institute For Subtropical Agricu

• Park Seong

  College Of Oriental Medicine Kyung Hee University

• Shin H‐y

  Kyung Hee Univ. Seoul Kor

• Kim Hyung-Ryong

  Department of Dental Pharmacology and Wonkwang Biomaterial Implant Research Institute, School of Dentistry, Wonkwang University

• Jeong Hyun-Ja

  College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University

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