Water Extracts of Immature Rubus coreanus Regulate Lipid Metabolism in Liver Cells
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概要
- 論文の詳細を見る
Hyperlipidemia is a major contributor for atherosclerosis and hypolipidemic drugs such as statin are highly prescribed to treat elevated lipid level in plasma. Rubus coreanus, which is widely cultivated in south eastern Asia, have been reported to show significant cholesterol lowering action in hyperlipidemic subjects. Our objective was to determine the cellular effect of Rubus coreanus extract (RCE) on cholesterol biosynthesis in human hepatic cells (HepG2) and to elucidate the molecular mechanism by which it causes change in cholesterol metabolism. RCE treatment lowered cholesterol biosynthesis as well as secretion from HepG2 cells. This effect was associated with lowering the release of apolipoproteins from hepatic cells. RCE treatment also showed an increase in phosphorylation of foxhead box protein 01 (FoXo-1) and 5-adenosine monophosphate-activated protein kinase (AMPK), thus lowering expression of phosphoenolpyruvate carboxykinase (PEPCK) and G6Pase, which might be a major pathway for cholesterol biosynthesis inhibition. Apart from this; RCE also lowered sterol regulatory element-binding protein-1 (SREBP-1) expression in HepG2 cells, showing a long term regulation of cholesterol biosynthesis activity. These results indicate that one of the anti-hyperlipidemic actions of RCE is due to inhibition of cholesterol biosynthesis in hepatic cells and provides first documentation of a hypolipidemic bio-molecular action of Rubus coreanus.
- 公益社団法人 日本薬学会の論文
著者
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Chae Han-jung
Department Of Dental Pharmacology And Wonkwang Dental Research Institute School Of Dentistry Wonkwan
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Chae Soo-wan
Department Of Pharmacology And Institute Of Cardiovascular Research School Of Medicine Chonbuk Natio
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Lee Geum-Hwa
Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk Nat
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Song Ji-Young
Gochang Black Raspberry Research Institute
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Kim Hyung-Ryong
Department of Dental Pharmacology and Wonkwang Biomaterial Implant Research Institute, School of Dentistry, Wonkwang University
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Lee Hee-Kwon
Gochang Black Raspberry Research Institute
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Kwon Ji-Wung
Gochang Black Raspberry Research Institute
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Bhandary Bidur
Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
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Marahatta Anu
Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
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Lee Hak-Yong
Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
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Kim Sun-Young
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital
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So Byung-Ok
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital
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Chae Han-Jung
Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
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Chae Soo-Wan
Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
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Lee Geum-Hwa
Department of Dental Pharmacology, Wonkwang Dental Research Institute, Dental School, Wonkwang University
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