Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells
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概要
- 論文の詳細を見る
Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine from rat peritoneal mast cells by compound 48/80 in a dose-dependent manner. LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction. LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-α expression in HMC-1 cells. In addition, LR also inhibited nuclear factor-kappa B (NF-κB) activation and IκB-α degradation. These results show that LR had an inhibitory effect on the atopic allergic reaction. Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases.
- 社団法人 日本農芸化学会の論文
著者
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Kim Hyung-Min
Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee
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Um Jae-Young
Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee
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Moon Phil-dong
College Of Oriental Medicine Kyung Hee University
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KIM Eun
Department of Phpysics, Hanyang University
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KIM Eun-Young
Department of Biotechnology, Pukyong National University
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Kim Yun-kyung
韓国
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MOON Phil-Dong
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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Jung Hyuk-sang
Department Of Anatomy College Of Oriental Medicine Kyung Hee University
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Park Seong
Department Of General Surgery College Of Medicine Chung-ang University
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LEE Hyun-Sam
Department of Anatomy, College of Oriental Medicine, Kyung Hee University
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SOHN Youngjoo
Deparment of Gynecology, College of Oriental Medicine, Sangji University
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SOHN Nak-Won
Department of Anatomy, College of Oriental Medicine, Kyung Hee University
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