Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Radix Paeoniae Alba has been used as a constituent of herbal medicine prescriptions for the treatment of inflammation, cancer, and other diseases. The aim of this study was to investigate the mechanism of Radix Paeoniae Alba extract (RPAE)-induced apoptosis in HL-60 leukemic cells. We observed that RPAE induced apoptotic changes in a dose-dependent manner, which was confirmed by DNA fragmentation and poly-(ADP-ribose) polymerase (PARP) cleavage. We also found release of cytochrome c from mitochondria to the cytosol in RPAE-treated HL-60 cells. The caspases, caspase-9 and -3, but not caspase-8, were found to be activated in response to RPAE treatment, and the caspase-3 inhibitor, Ac-DEVD-CHO, and the caspase-9 inhibitor, z-LEHD-FMK, but not the caspase-8 inhibitor, z-IETD-FMK, attenuated RPAE-induced DNA fragmentation and PARP cleavage. These results suggest that RPAE-induced apoptosis is stimulated by the release of cytochrome c to the cytosol, by procaspase-9 processing, and via a caspase-3 dependent mechanism.
- 公益社団法人日本薬学会の論文
- 2006-06-01
著者
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Park Jin
Department of Internal Medicine, Sejong General Hospital
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KIM Eun
Department of Phpysics, Hanyang University
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LEE Young
Department of Food Science and Nutrition, Pusan National University
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Park Byung
Department Of Internal Medicine Seoul National University College Of Medicine
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Park Jin
Department Of Biochemistry Medical School Chonbuk National University
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Kwon Kang
Department Of Physiology School Of Oriental Medicine Won-kwang University
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Park Byung
Department Of Biochemistry Medical School Chonbuk National University
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Lee Young
Department Of Aerospace Information Engineering The Konkuk University
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Han Mi
Department Of Physiology School Of Oriental Medicine Wonkwang University
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Lee Young
Department Of Biochemistry Medical School Chonbuk National University:institute For Healthcare Techn
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Kim Eun
Department Of Biochemistry Medical School Chonbuk National University
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SHIN Byung
Rehabilitation, School of Oriental Medicine, Wonkwang University
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PARK Yong
Internal Medicine, School of Oriental Medicine, Wonkwang University
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KIM Kang
Internal Medicine, School of Oriental Medicine, Wonkwang University
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RYU Do
Department of Physiology, School of Oriental Medicine, Wonkwang University
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Shin Byung
Rehabilitation School Of Oriental Medicine Wonkwang University
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Ryu Do
Department Of Physiology School Of Oriental Medicine Wonkwang University
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Han Mi
Department Of Materials Science And Engineering Faculty Of Engineering
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Kim Eun
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Kim Kang
Internal Medicine School Of Oriental Medicine Wonkwang University
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Park Jin
Department Of Anatomy Ajou University School Of Medicine
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Park Yong
Internal Medicine School Of Oriental Medicine Wonkwang University
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Park Jin
Department of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic of Korea
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KIM Eun
Department of Agricultural Biotechnology, Seoul National University
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