Altered Immune Cell Proportions in the Radiodermatitis Induced Hairless Mice-1 (HR-1)
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概要
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Accidental radiation exposures or radiation therapy can cause internal and external damage including radiodermatitis. Even though radiodermatitis is one of the dose limiting factors in radiotherapy, the immunological nature of it is not yet been clearly understood. In this study, we have examined the alteration in immune cell population during the radiodermatitis process. A radiodermatitis model was established in HR-1 mice by locally exposing a posterior dorsal region to 10 Gy X-ray/day for 4 consecutive days. Collagen accumulation, redness, erythema, and dry desquamation of the skin were detected after X-irradiation. The size and total cell number of the spleen decreased immediately after X-irradiation, compared to those of the sham-irradiated mice, and recovered to the normal levels two weeks later. Reduction and recovery of the bone marrow cell population preceded a similar change of the spleen cell population. The proportion of CD4^+ T cell increased, while the proportion of CD8^+ T cell decreased ahead of the obvious skin damage, in both lymph node and spleen of the irradiated mice. Interestingly, the proportion of splenic monocytes/macrophages was expanded gradually at a similar kinetics with the aggravation of the radiodermatitis. The infiltration of the CD11b^+ monocyte/macrophage to the X-irradiated skin also coincided with the development of radiodermatitis. These altered proportions of immune cells may play important roles in radiodermatitis.
- 日本放射線影響学会の論文
- 2006-03-31
著者
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Cho Moon
Department of Obstetrics and Gynecology, Chonnam National University Medical School
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LEE Suk
Research Institute of Immunobiology, Department of Biomedical Sciences, Catholic University of Korea
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LEE Young
Department of Food Science and Nutrition, Pusan National University
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Lee Jeung-hoon
Department Of Dermatology And Research Institute For Medical Sciences School Of Medicine
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Cho Moon
Department Of Radiation Oncology College Of Medicine Chungnam National University
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Cho Moon
Department Of Chemistry Kangweon National University
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Choi Dae
Department Of Dermatology
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Kim Tae-yoon
Department Of Dermatology College Of Medicine The Catholic University Of Korea
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Kim Tae-yoon
Departmenr Of Industrial Chemistry College Of Engineering Kon Kuk University
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CHA Jung-Ho
Department of Electrical Engineering and Computer Science, Korea Advanced Institute of Science and T
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Lee Young
Department Of Aerospace Information Engineering The Konkuk University
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Cha Jung-ho
Department Of Anatomy
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Cho Sung
Research Institute Of Immunobiology
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Kwon Hyung-joo
Department Of Microbiology College Of Medicine Hallym University
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Lee Jeung-hoon
Department Of Dermatology
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Lee Suk
Research Institute Of Immunobiology Department Of Biomedical Sciences Catholic University Of Korea
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MAENG Hyung
Research Institute of Immunobiology
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KIM Do
Research Institute of Immunobiology
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Lee Young
Department Of Dermatology
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Choi Dae
Department Of Chemical Engineering Dongeui University
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Lee Suk
Research Institute Of Immunobiology
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KIM Tae-Yoon
Department of Dermatology, College of Medicine, The Catholic University of Korea
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