Inhibition of Cytokine-Mediated Nitric Oxide Synthase Expression in Rat Insulinoma Cells by Scoparone(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
Cytokines produced by immune cells infiltrating pancreatic islets are important mediators of β-cell destruction in insulin-dependent diabetes mellitus. Scoparone (6,7-dimethoxycoumarin) is known to have a wide range of pharmacological properties in vitro. In this study, the effects of scoparone on cytokine-induced β-cell dysfunction were examined. Presence of scoparone significantly protected interleukin-1β (IL-1β) and interferon-γ (IFN-γ)-mediated cytotoxicity of RINm5F, a rat insulinoma cell line, and preserved glucose-stimulated insulin secretion in rat pancreatic islets. Scoparone also resulted in a significant reduction in IL-1β and IFN-γ-induced nitric oxide (NO) production, a finding that correlated well with reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein. The molecular mechanism by which scoparone inhibited iNOS gene expression appeared to involve the inhibition of NF-κB activation. These results revealed the possible therapeutic value of scoparone for the prevention of diabetes mellitus progression.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
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Park Jin
Department of Internal Medicine, Sejong General Hospital
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KIM Eun
Department of Phpysics, Hanyang University
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Park Byung
Department Of Internal Medicine Seoul National University College Of Medicine
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LEE Ju
Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Med
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Park Jin
Department Of Biochemistry Medical School Chonbuk National University
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Kwon Kang
Department Of Physiology School Of Oriental Medicine Won-kwang University
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Park Byung
Department Of Biochemistry Medical School Chonbuk National University
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Yang Jeong
Department of Medicine, Cardiac and Vascular Center, Sungkyunkwan University School of Medicine, Sam
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Lee Ju
Department Of Preventive Medicine Medical School Chonbuk National University
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Jhee Eun
Department Of Biochemistry Dental School Chonbuk National University
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Yang Jeong
Department Of Biochemistry Dental School Chonbuk National University
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Lee Ju
Department Of Applied Sciences Korea Maritime University
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Kim Eun
Department Of Biochemistry Medical School Chonbuk National University
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LEE Hern
Department of Immunology, Medical School, Chonbuk National University
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Lee Hern
Department Of Immunology Medical School Chonbuk National University
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Kim Eun
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
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Park Jin
Department Of Anatomy Ajou University School Of Medicine
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Park Jin
Department of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic of Korea
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KIM Eun
Department of Agricultural Biotechnology, Seoul National University
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LEE Ju
Department of Applied Plant Sciences, College of Agriculture and Life Sciences, Kangwon National University
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