Comparative Effect of Gromwell (Lithospermum erythrorhizon) Extract and Borage Oil on Reversing Epidermal Hyperproliferation in Guinea Pigs
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概要
- 論文の詳細を見る
To compare the systemic efficacy of borage oil (Borago officinalis: BO) and gromwell (Lithospermum erythrorhizon), two plant species of the Boraginaceae family, epidermal hyperproliferation was induced in guinea pigs by a hydrogenated coconut oil diet for 8 weeks. Subsequently, guinea pigs were fed diets of BO (group HBO), organic extract (group HGO), or water extract (group HGW) of gromwell for 2 weeks. In groups HGO and HGW, proliferation scores and the level of ceramides, the major lipid maintaining epidermal barrier, were similar with those in normal control group BO fed BO diet for 10 weeks. Despite accumulation of 15-hydroxyeicosatrienoic acid (15-HETrE), the potent anti-proliferative metabolite of γ-linolenic acid (GLA: major polyunsaturated fatty acid in BO), the reversal of epidermal hyperproliferation and the ceramide level of group HBO were less than those of groups HGO and HGW. Taken together, our data demonstrate that gromwell is more effective in reversing epidermal hyperproliferation with a marked increase in ceramides.
- 社団法人 日本農芸化学会の論文
- 2007-09-23
著者
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Kim Sung
Nutrex Co. Ltd.
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Park Seong
Department Of General Surgery College Of Medicine Chung-ang University
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Fujii Tadashi
Bioresource Laboratories Mercian Corp. 1808 Nakaizumi Iwata Shizuoka 438-0078 Jpn
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Jeong Do
Nutrex Co. Ltd.
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KIM Juyoung
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University
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KIM Hyunae
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University
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CHO Yunhi
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University
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Cho Yunhi
Department Of Medical Nutrition Graduate School Of East-west Medical Science Kyung Hee University
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Kim Hyunae
Department Of Medical Nutrition Graduate School Of East-west Medical Science Kyung Hee University
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Kim Juyoung
Department Of Medical Nutrition Graduate School Of East-west Medical Science Kyung Hee University
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Johdo Osamu
Bioresource Laboratories Mercian Co.
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Nakamura Takumi
Sodx Co. 206-1 Kagata Kawachinagano
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SUGIMOTO Satoshi
Bioresource Laboratories, Mercian Co.
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MORIMIYA Tatsuo
Bioresource Laboratories, Mercian Co.
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Morimiya Tatsuo
Bioresource Laboratories Mercian Co.
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Sugimoto Satoshi
Bioresource Laboratories Mercian Co.
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Fujii Tadashi
Bioresource Laboratories Mercian Co.
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Kim Juyoung
Bioresource Laboratories, Mercian Co.
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Kim Hyunae
Bioresource Laboratories, Mercian Co.
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Jeong Do
Bioresource Laboratories, Mercian Co.
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NAKAMURA Takumi
Sodx Co.
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