Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma(Medicinal Chemistry)
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概要
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Our preliminary study demonstrated that 70% ethanol Cortidis Rhizoma extracts (CR) had a hypoglycemic action in diabetic animal models. We determined whether CR fractions acted as anti-diabetic agent, and a subsequent investigation of the action mechanism of the major compound, berberine ([C_<20>H_<18>NO_4]^+), was carried out in vitro. The 20, 40 and 60% methanol fractions from the XAD-4 column contained the most insulin sensitizing activities in 3T3-L1 adipocytes. The common major peak in these fractions was berberine. Treatment with 50μM berberine plus differentiation inducers significantly reduced triglyceride accumulation by decreased differentiation of 3T3-L1 fibroblasts to adipocytes and triglyceride synthesis. Significant insulin sensitizing activity was observed in 3T3-L1 adipocytes which were given 50μM berberine plus 0.2nM insulin to reach a glucose uptake level increased by 10nM of insulin alone. This was associated with increased glucose transporter-4 translocation into the plasma membrane via enhancing insulin signaling pathways and the insulin receptor substrate-1-phosphoinositide 3 Kinase-Akt. Berberine also increased glucose-stimulated insulin secretion and proliferation in Min6 cells via an enhanced insulin/insulin-like growth factor-1 signaling cascade. Data suggested that berberine can act as an effective insulin sensitizing and insulinotropic agent. Therefore, berberine can be used as anti-diabetic agent for obese diabetic patients.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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Jang Jin
Department of Physics, Kyunghee University Hoigi-dong
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Kim Yeong
Department Of Mathematics And Center For Applied Mathematics Korea Advanced Institute Of Science And
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Jang Jin
Department Of Biochemistry School Of Medicine Kyungpook National University
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Jang Jin
Deptartment Of Food And Nutrition Hoseo Univ.
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Park Seong
Department Of General Surgery College Of Medicine Chung-ang University
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Choi Soo
Department Of Forest And Forest Products Sciences Fuculty Of Agriculture Kyushu Unviversity
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PARK Sunmin
Department of Food and Nutrition, Obesity and Diabetes Research Institute, Hoseo University
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KO Byoung
Department of Quality Control and Inspection, Korea Institute of Oriental Medicine
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Ko Byoung-seob
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Ko Byoung
Department Of Orthopedic Surgery College Of Medicine Kyung Hee University
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Park Sunmin
Deptartment Of Food And Nutrition Hoseo Univ.
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Park Sunmin
Deptartment Of Food And Nutrition Coll. Of Natural Sci. Hoseo Univ.
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Ko Byoung
Deptartment Of Quality Control And Inspection Korea Institute Of Oriental Medicine
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Park Sunmin
Department Of Food And Nutrition College Of Natural Science Hoseo University
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Choi Soo
Department Of Anesthesiology And Pain Medicine Samsung Medical Center Sungkyunkwan University School
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Kim Yeong
Department Of Quality Inspection And Examination Korea Institute Of Oriental Medicine
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Park Seong
Department Of Oriental Medicine Kyunghee University
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Choi Soo
Department Of Advanced Materials Engineering (polymerics Program) Korea Advanced Institute Of Scienc
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Choi Soo
韓国
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Park Sunmin
Department Of Climatic Environment Graduate School Of Life And Environmental Science Korea Universit
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PARK Seong
Department of Computer Engineering, Chonnam National University
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