Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 Cells via PKA-Dependent Pathways
スポンサーリンク
概要
- 論文の詳細を見る
Ginseng root is known to induce anti-diabetic activity, but the key components involved are unknown. We investigated which major ginsenosides in ginseng enhanced glucose homeostasis by in vitro studies. Rb1 and Rg1 reduced the triglyceride accumulation in 3T3-L1 adipocytes by activating PKA with increased intracellular cAMP. However, the insulin-stimulated glucose uptake was enhanced by Rb1 and Rg1 via activation of phosphatidylinositol-3 kinase. Rb1 and Rg1 promoted glucose-stimulated insulin secretion and cell viability in Min6 cells through PKA which augmented IRS2 expression to enhance insulin/IGF-1 signaling. These results suggest that Rb1 and Rg1 improved glucose homeostasis through the activation of a PKA like glucagon-like peptide-1 receptor agonist.
- 社団法人 日本農芸化学会の論文
- 2008-11-23
著者
-
Kwon Dae
Food Function Res. Div. Korea Food Res. Inst.
-
Kwon Dae
Emerging Innovative Technology Research Division Korean Food Research Institutes
-
AHN Il
Department of Food and Nutrition, Obesity and Diabetes Research Institute, Hoseo University
-
PARK Sunmin
Department of Food and Nutrition, Obesity and Diabetes Research Institute, Hoseo University
-
KO Byoung
Department of Quality Control and Inspection, Korea Institute of Oriental Medicine
-
JUN Won
Department of Quality Control and Inspection, Korea Institute of Oriental Medicine
-
Ahn Il
Department Of Food And Nutrition Obesity And Diabetes Research Institute Hoseo University
-
Ko Byoung
Department Of Orthopedic Surgery College Of Medicine Kyung Hee University
-
Park Sunmin
Department Of Food And Nutrition Obesity And Diabetes Research Institute Hoseo University
-
Ko Byoung
Department Of Quality Control And Inspection Korea Institute Of Oriental Medicine
-
Ahn Il
Department Of Food And Nutrition College Of Natural Science Hoseo University
-
Park Sunmin
Department Of Food And Nutrition College Of Natural Science Hoseo University
-
Jun Won
Department Of Quality Control And Inspection Korea Institute Of Oriental Medicine
-
Park Sunmin
Department Of Climatic Environment Graduate School Of Life And Environmental Science Korea Universit
関連論文
- 一過性大脳虚血を施したスナネズミ皮質体性感覚野におけるGlutamic acid decarboxylase 67免疫反応性ならびにタンパク質レベルの一過性増加(解剖学)
- Exendin-4 Potentiates Insulinotropic Action Partly via Increasing β-Cell Proliferation and Neogenesis and Decreasing Apoptosis in Association With the Attenuation of Endoplasmic Reticulum Stress in Islets of Diabetic Rats
- Metabolite Profiling of Cheonggukjang, a Fermented Soybean Paste, Inoculated with Various Bacillus Strains during Fermentation
- Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 Cells via PKA-Dependent Pathways
- In vitro and Short-term in vivo Characteristics of a Kel-F Thin Film Modified Glucose Sensor
- A Steroidal Glycoside from Polygonatum odoratum (Mill.) Druce. Improves Insulin Resistance but does not Alter Insulin Secretion in 90% Pancreatectomized Rats(Food & Nutrition Science)
- Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma(Medicinal Chemistry)
- Metabolite Profiling of Cheonggukjang, a Fermented Soybean Paste, Inoculated with Various Bacillus Strains during Fermentation
- Huang-Lian-Jie-Du-Tang Supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce Improved Glucose Tolerance by Potentiating Insulinotropic Actions in Islets in 90% Pancreatectomized Diabetic Rats
- Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 Cells via PKA-Dependent Pathways
- 関節鏡的足関節固定術
- Vulnerability Assessment of Forest Ecosystem to Climate Change in Korea Using MC1 Model(Multipurpose Forest Management)