Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 Cells via PKA-Dependent Pathways

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概要

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• Ginseng root is known to induce anti-diabetic activity, but the key components involved are unknown. We investigated which major ginsenosides in ginseng enhanced glucose homeostasis by in vitro studies. Rb1 and Rg1 reduced the triglyceride accumulation in 3T3-L1 adipocytes by activating PKA with increased intracellular cAMP. However, the insulin-stimulated glucose uptake was enhanced by Rb1 and Rg1 via activation of phosphatidylinositol-3 kinase. Rb1 and Rg1 promoted glucose-stimulated insulin secretion and cell viability in Min6 cells through PKA which augmented IRS2 expression to enhance insulin/IGF-1 signaling. These results suggest that Rb1 and Rg1 improved glucose homeostasis through the activation of a PKA like glucagon-like peptide-1 receptor agonist.

• 社団法人 日本農芸化学会の論文

著者

• Kwon Dae

  Food Function Res. Div. Korea Food Res. Inst.

• AHN Il

  Department of Food and Nutrition, Obesity and Diabetes Research Institute, Hoseo University

• PARK Sunmin

  Department of Food and Nutrition, Obesity and Diabetes Research Institute, Hoseo University

• KO Byoung

  Department of Quality Control and Inspection, Korea Institute of Oriental Medicine

• JUN Won

  Department of Quality Control and Inspection, Korea Institute of Oriental Medicine

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• Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 Cells via PKA-Dependent Pathways

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