Evaluation of Anti-allergic Effects of 1-Substituted 2-n-Butyl-methylenedioxy Indenes
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概要
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The effects of ten 1-substituted 2-n-butyl-5,6-methylenedioxyindenes on mice and guinea pigs were investigated for their allergic reactions in the development of a new anti-allergic drug. Antiallergic effects were determined by testing the effect of agents on passive cutaneous anaphylaxis (PCA) in mice and Schultz-Dale reaction in guinea pig tracheal muscle. 2-Butyl-1-[N-methyl-N-[2-(N', N'-dimethylamino) ethyl] amino]-5,6-methylenedioxyindene (1) indicated the most potent anti-allergic activity. Since our previous experiments indicated that 2-n-butyl 3-dimethyl amino-5,6-methylenedioxyindene (MDI-A) and its derivatives showed a potent anti-allergic effect by interfering with the calcium (Ca) movement in the allergic reaction in guinea pigs, the effect of 1 and MDI-A on allergic reaction and Ca-induced contraction of tracheal muscle in these animals were compared. The present data indicate the superiority of 1 in both reactions.
- 公益社団法人日本薬学会の論文
著者
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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Koda Akihide
岐阜薬科大学 薬
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Hara Satoshi
Department of Geriatric Dentistry, Showa University, School of Dentistry
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Choi Soo
Department Of Forest And Forest Products Sciences Fuculty Of Agriculture Kyushu Unviversity
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KODA AKIHIDE
Department of Pharmacology, Gifu College of Pharmacy
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Xu Q
Nanotechnology Research Institute National Institute Of Advanced Industrial Science And Technology (
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Xu Qiang
Department Of Chemical Engineering Tsinghua University
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YAKUO Ikuhisa
Department of Pharmacology, Gifu Pharmaceutical University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Yakuo Ikuhisa
Department Of Pharmacology Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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Yakuo I
Dainippon Pharmaceutical Co. Ltd. Osaka Jpn
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Choi Soo
Department Of Anesthesiology And Pain Medicine Samsung Medical Center Sungkyunkwan University School
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Xu Q
Nanotechnology Research Institute National Institute Of Advanced Industrial Science And Technology (
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Choi Soo
Department Of Advanced Materials Engineering (polymerics Program) Korea Advanced Institute Of Scienc
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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Xu Qiang
Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
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