Effects of a New Antiallergic Drug, VUF-K-8788, on Infiltration of Lung Parenchyma by Eosinophils in Guinea Pigs and Eosinophil-Adhesion to Human Umbilical Vein Endothelial Cells(HUVEC)

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概要

• 論文の詳細を見る

• Airway inflammation and reversible airway obstruction are hallmarks of bronchial asthma. In this study, we investigated the effects of a new antiallergic drug, 7-{3-[4-(2-quinolinylmethyl)-1-piperazinyl]-propoxy}-2, 3-dihy-dro-4H-1, 4-benzothiazin-3-one(VUF-K-8788), on histopathological changes in lung parenchyma of guinea pigs during late-phase asthmatic reaction(LAR), and on eosinophil-adhesion to human umbilical vein endothelial cells(HUVEC). Repeated exposure to ovalbumin of sensitized guinea pigs induced inflammatory phenomena such as hyper-plasia of airway epithelial cells, perivascular edema and infiltration of lung parenchyma by eosinophils. VUF-K-8788 inhibited these histopathological phenomena at 10mg/kg p.o. Moreover, the eosinophil-adherence to HUVEC was inhibited by VUF-K-8788 at the concentration of 10-30μM. In conclusion, this inhibitory effect of VUF-K-8788 on eosinophil-adherence might contribute to the prevention or LAR and infiltration by eosinophils in the experimental asthmatic model in guinea pigs.

• 社団法人日本薬学会の論文
• 2001-10-01

著者

• NAGAI Hiroichi

  Department of Pharmacology, Gifu Pharmaceutical University

• Saiki Ikuo

  富山大学 薬学研究科応用薬理学

• Saiki I

  Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama

• TAKIZAWA Toshiaki

  Department of Pharmacology, Gifu Pharmaceutical University

• WATANABE Chie

  Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University

• SAIKI Ikuo

  Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University

• WADA Yasushi

  Tokyo Research Laboratories, Kowa Company Ltd.

• TOHMA Tsutomu

  Tokyo Research Laboratories, Kowa Company Ltd.

• SAIKI Ikuo

  Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama

• Wada Yasushi

  Tokyo Research Laboratories Pharmaceutical Division Kowa Company Ltd

• Takizawa Toshiaki

  Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.

• Takizawa Toshiaki

  興和

• Takizawa Toshiaki

  岐阜薬科大学 薬理

• Saiki Ikuo

  Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama

• Saiki I

  Institute Of Natural Medicine University Of Toyama

• Nagai Hiroichi

  Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University

• Saiki Ikuo

  Department Of Pathological Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceuti

• Wada Yasushi

  Tokyo Research Laboratories Kowa Co. Ltd.

• Saiki Ikuo

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Nagai Hiroichi

  Department Of Clinical Pharmacology Gifu Pharmaceutical University

• Takizawa Toshiaki

  Department Of Neurosurgery Central Hospital Of Japaneae National Railways

• Nishida Hiroyuki

  Department Of Pharmacology Gifu Pharmaceutical University

• Saiki Ikuo

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Nagai Hiroichi

  Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama

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