Effects of a New Antiallergic Drug, VUF-K-8788, on Infiltration of Lung Parenchyma by Eosinophils in Guinea Pigs and Eosinophil-Adhesion to Human Umbilical Vein Endothelial Cells(HUVEC)
スポンサーリンク
概要
- 論文の詳細を見る
Airway inflammation and reversible airway obstruction are hallmarks of bronchial asthma. In this study, we investigated the effects of a new antiallergic drug, 7-{3-[4-(2-quinolinylmethyl)-1-piperazinyl]-propoxy}-2, 3-dihy-dro-4H-1, 4-benzothiazin-3-one(VUF-K-8788), on histopathological changes in lung parenchyma of guinea pigs during late-phase asthmatic reaction(LAR), and on eosinophil-adhesion to human umbilical vein endothelial cells(HUVEC). Repeated exposure to ovalbumin of sensitized guinea pigs induced inflammatory phenomena such as hyper-plasia of airway epithelial cells, perivascular edema and infiltration of lung parenchyma by eosinophils. VUF-K-8788 inhibited these histopathological phenomena at 10mg/kg p.o. Moreover, the eosinophil-adherence to HUVEC was inhibited by VUF-K-8788 at the concentration of 10-30μM. In conclusion, this inhibitory effect of VUF-K-8788 on eosinophil-adherence might contribute to the prevention or LAR and infiltration by eosinophils in the experimental asthmatic model in guinea pigs.
- 社団法人日本薬学会の論文
- 2001-10-01
著者
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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Saiki Ikuo
富山大学 薬学研究科応用薬理学
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Saiki I
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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TAKIZAWA Toshiaki
Department of Pharmacology, Gifu Pharmaceutical University
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WATANABE Chie
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
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SAIKI Ikuo
Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
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WADA Yasushi
Tokyo Research Laboratories, Kowa Company Ltd.
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TOHMA Tsutomu
Tokyo Research Laboratories, Kowa Company Ltd.
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SAIKI Ikuo
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama
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Wada Yasushi
Tokyo Research Laboratories Pharmaceutical Division Kowa Company Ltd
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Takizawa Toshiaki
Tokyo New Drug Research Laboratories Ii Pharmaceutical Division Kowa Company Ltd.
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Takizawa Toshiaki
興和
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Takizawa Toshiaki
岐阜薬科大学 薬理
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Saiki Ikuo
Division Of Pathogenic Biochemistry Institute Of Natural Medicine University Of Toyama
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Saiki I
Institute Of Natural Medicine University Of Toyama
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Nagai Hiroichi
Laboratory Of Pharmacology Department Of Bioactive Molecules Gifu Pharmaceutical University
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Saiki Ikuo
Department Of Pathological Biochemistry Institute Of Natural Medicine Toyama Medical And Pharmaceuti
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Wada Yasushi
Tokyo Research Laboratories Kowa Co. Ltd.
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Saiki Ikuo
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Takizawa Toshiaki
Department Of Neurosurgery Central Hospital Of Japaneae National Railways
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Nishida Hiroyuki
Department Of Pharmacology Gifu Pharmaceutical University
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Saiki Ikuo
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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