High Rate of IgE-Mediated Histamine Release from Rat Mesenteric Mast Cells
スポンサーリンク
概要
- 論文の詳細を見る
IgE-dependent histamine release from rat mesenteric mast cells was investigated. Excised mesenterium was cut into pieces and incubated with IgE overnight at 4°C for sensitization. Over 10 pieces of mesenterium specimen could be prepared from a rat. Antigen-induced histamine release from mesenterium specimen was initiated rapidly and reached a plateau in 5 min. In an optimal condition, over 50% of total histamine was released. In contrast, unpurified and purified peritoneal mast cells released only 22.5% and 5.3% of total histamine, respectively, upon IgE stimulation. Tranilast, a mast cell stabilizer, inhibited the histamine release from mesenteric mast cells significantly. The mesenterium might be a useful material for studying tissue-associated mast cell activation.
- 社団法人 日本実験動物学会の論文
著者
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Nii Hiroaki
岐阜薬科大学 薬理学
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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KAWASAKI Hirokazu
Department of Pharmacology, Gifu Pharmaceutical University
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Kawasaki Hirokazu
岐阜薬科大学 薬理
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Kawasaki Hirokazu
Department Of Pharmacology Gifu Pharmaceutical University
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INAGAKI Naoki
Pharmacological Department, Gifu College of Pharmacy
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Inagaki Naoki
Laboratory Of Bioresponses And Regulation United Graduate School Of Drug Discovery And Medical Information Science Gifu University
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Nagai Hiroichi
Pharmacological Department Gifu College Of Pharmacy
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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KAWASAKI Hirokazu
Department of Hospital Pharmacy
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