Peritoneal Mast Cell Hyperplasia in Rats after IgE Antibody-Antigen Interaction
スポンサーリンク
概要
- 論文の詳細を見る
Peritoneal mast cell hyperplasia was investigated in rats after evoking IgE antibody-antigen reaction. Rats were immunized with antigen and then passively sensitized with monoclonal IgE antibody before antigen challenge. A significant increase in the number of peritoneal mast cells was observed 3 weeks after the antigen challenge in the peritoneal cavity, although the histamine content of the mast cells was decreased significantly. In rats without prior immunization, these changes were not observed. Stimulation with compound 48/80 or calcium ionophore A23187 did not affect the number of mast cells. This model may prove to be a useful tool for studying the mechanisms of mast cell hyperplasia and recruitment of mast cell precursors in vivo.
- 社団法人 日本実験動物学会の論文
- 1995-10-01
著者
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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KAWASAKI Hirokazu
Department of Pharmacology, Gifu Pharmaceutical University
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Kawasaki Hirokazu
岐阜薬科大学 薬理
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Kawasaki Hirokazu
Department Of Pharmacology Gifu Pharmaceutical University
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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BABA Ayako
Department of Pharmacology, Gifu Pharmaceutical University
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Pharmacological Department Gifu College Of Pharmacy
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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KAWASAKI Hirokazu
Department of Hospital Pharmacy
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