EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS
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概要
- 論文の詳細を見る
The effect of cinnarizine on immunoglobulin E (IgE) antibody mediated allergic reactions in mice and rats was investigated. Nifedipine and tranilast were used as comparative drugs. 1) The dye leakage caused by IgE antibody mediated passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by cinnarizine administered both orally and intraperitoneally. The inhibitory action of cinnarizine for PCA was as potent as nifedipine and superior to tranilast. 2) Cinnarizine clearly inhibited the increase in capillary permeability caused by histamine and calcium ionophore A 23187 (A 23187) but not by LTD_4 in mouse ear. Nifedipine inhibited the increases of capillary permeability caused by A 23187,histamine and LTD_4. Tranilast inhibited A 23187 induced vasculitis but not histamine or LTD_4-induced reaction. 3) Cinnarizine had no significant effect on the release of histamine caused by antigen or A 23187 from rat peritoneal mast cells. Nifedipine and tranilast inhibited the release of histamine caused by both antigen and A 23187 from rat peritoneal mast cells.
- 公益社団法人日本薬学会の論文
著者
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Koda Akihide
岐阜薬科大学 薬
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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YAMADA Hiroaki
Department of Chemistry, Faculty of Science, Kobe University
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Koda Akihide
Department Of Pharmacology Gifu College Of Pharmacy
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Yakuo Ikuhisa
Department Of Pharmacology Exploratory Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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GOTO SHOICHI
Department of Pharmacology, Gifu Pharmaceutical University
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Yakuo I
Dainippon Pharmaceutical Co. Ltd. Osaka Jpn
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Yamada Hiroaki
Department Of Chemistry Faculty Of Science Chiba Univeristy
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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