Synthesis of Benzimidazole Derivatives as Antiallergic Agents with 5-Lipoxygenase Inhibiting Action
スポンサーリンク
概要
- 論文の詳細を見る
Syntheses were conducted of novel benzimidazole derivatives that suppress histamine release from mast cells, inhibit 5-lipoxygenase, and possess antioxidative action. Among the compounds synthesized, 1-[2-[2-(4-hydroxy-2,3,5-trimethylphenoxy)ethoxy]ethyl]-2-(4-methyl-1-homopiperazino)benzimidazole (22) potently suppressed histamine release from rat peritoneal mast cells triggered by the antigen-antibody reaction, inhibited 5-lipoxygenase in rat basophilic leukemia-1 (RBL-1) cells, and prevented the NADPH-dependent lipid peroxidation induced by Fe^<3+>-ADP in rat liver microsomes, in addition to an antagonizing the contraction of guinea pig ileum caused by histamine.
- 公益社団法人日本薬学会の論文
- 1999-11-15
著者
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田口 武夫
東京薬科大学薬学部
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INAGAKI Naoki
Department of Pharmacology, Gifu Pharmaceutical University
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NAGAI Hiroichi
Department of Pharmacology, Gifu Pharmaceutical University
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SATOH Toshio
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Satoh T
Yakuhan Pharmaceutical Co. Ltd. Hokkaido Jpn
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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Inagaki Naoki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Nakano H
Department Of Physics And Astronomy And Center For Gravitational Wave Astronomy The University Of Te
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Nakano H
Lithography Tech. Dept. Sony Corporation Msnc
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Nagai Hiroichi
Department Of Clinical Pharmacology Gifu Pharmaceutical University
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Satoh Toshio
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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KAWASAKI Nobuhide
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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MIYATAKA Hideki
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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NAKANO Hiroyuki
Theoretical Astrophysics, California Institute of Technology Pasadena
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NAKANO Hiroyuki
Organic Chemistry Department, Research Laboratories, Fujiyakuhin Co., Ltd.,
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INOUE Tsutomu
Organic Chemistry Department, Research Laboratories, Fujiyakuhin Co., Ltd.,
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MATSUMOTO Hitoshi
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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TAGUCHI Takeo
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Taguchi Takeo
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Satoh Toshio
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Miyataka Hideki
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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Inagaki Naoki
Departmen T Of Pharmacology Gifu Pharmaceutical University
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Satoh Toshio
Faculty Of Pharmaceutical Science Tokushima Bunri University
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Matsumoto Hitoshi
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Matsumoto Hitoshi
School Of Pharmacy Tokushima University Of Arts And Science
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Miyataka Hideki
Department Of Bio-organic Medicinal Chemistry Faculty Of Pharmaceutical Sciences Tokushima Bunri Uni
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Nagai Hiroichi
Department Of Applied Pharmacology Graduate School Of Medicine And Pharmaceutical Sciences University Of Toyama
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NAKANO Hiroyuki
Department of Physics and Astronomy, and Center for Gravitational Wave Astronomy, The University of Texas at Brownsville
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NAKANO Hiroyuki
Department of Earth and Space Science, Graduate School of Science Osaka University
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