Studies on Organic Fluorine Compounds. XXXIX. Studies on Steroids. LXXIX. Synthesis of 1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D_3
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概要
- 論文の詳細を見る
1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorocholesterol was synthesized by two procedures. Cholenic acid was converted to the 1α-hydroxy-24-sulfone derivative and hexafluoroacetone was reacted with the lithiated 24-sulfone. Subsequent removal of the sulfonyl group afforded the hexafluoro-1α, 25-dihydroxy compound. An alternative process consists of construction of the hexafluoro-25-hydroxy part on the side chain followed by the introduction of a hydroxy group at the 1α-position. The hexafluoro derivative was converted to the vitamin D form, 1α, 25-dihydroxyhexafluorovitamin D_3,via the corresponding 5,7-diene.
- 公益社団法人日本薬学会の論文
- 1982-12-25
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
Tokyo College of Pharmacy
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田口 武夫
Tokyo College of Pharmacy
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江口 正
Iwaki Meisei University
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小林 義郎
東京薬科大学薬学部
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池川 信夫
新潟薬大
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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江口 正
Department of Chemistry, Tokyo Institute of Technology
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大島 悦男
Department of Chemistry, Tokyo Institute of Technology
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大島 悦男
Department Of Chemistry Tokyo Institute Of Technology
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三橋 智
Tokyo College Of Pharmacy
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大島 悦夫
Department of Chemistry, Tokyo Institute of Technology
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