Studies on the Reaction of Heterocyclic Compounds. XV. N-Alkylation of 1,2,3,4-Tetrahydro-5-methyl-1,6-naphthyridine
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Alkylation of 1-position of 5-methyl-1,2,3,4-tetrahydro-1,6-naphthyridine (I) does not proceed in ordinary methods. I shows quite peculiar behavior in ultraviolet spectrum ; absorption maximum shows bathochromic shift on protonation. Based on these data alkylation was successfully carried out in the presence of sodium amide.
- 1976-08-25
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