Studies on Organic Fluorine Compounds. XLV. Synthesis and Regioselective Substitution Reaction of 3-Trifluoromethylfuran
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概要
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3-Trifluoromethylfuran (1) was efficiently synthesized by the reaction of 4-methyloxazole with 3,3,3-trifluoropropyne. Lithiation of 1 with n-butyllithium followed by reaction with an electrophile gave the corresponding 2-substituted 3-trifluoromethylfuran (4). Starting from 2-triethylsilyl-3-trifluoromethylfuran (4a), 2-substituted 4-trifluoromethylfurans (6) were synthesized.
- 1985-09-25
著者
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小林 義郎
Tokyo College of Pharmacy
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河田 恒佐
Tokyo College of Pharmacy
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北川 理
Tokyo College of Pharmacy
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北川 理
東京薬科大学薬学部
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