Studies on Organic Flourine Compounds. V. Preparations and Reactions of N-Oxides of Trifluoromethylated Pyridines
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First, N-oxidation of trifluoromethylated pyridines was carried out. The three isomers of trifluoromethylpyridine were successfully N-oxidized using acetic acid and hydrogen peroxide, but with 2,4- and 2,6-bis (trifluoromethyl) isomers of bis (trifluoromethyl) pyridine, N-oxidation was successful only when trifluoroacetic acid and hydrogen peroxide were used. Next, the reaction of the N-oxides of the three isomers of (trifluoromethyl) pyridine with acetic anhydride and their Reissert reaction were carried out ; the effect of trifluoromethyl group was very marked. The success in the Reissert reaction with pyridine series is only second to that with 4-chloropyridine 1-oxide.
- 公益社団法人日本薬学会の論文
- 1969-03-25
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