Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
スポンサーリンク
概要
- 論文の詳細を見る
Fluorinated analogs of Leu-enkephalin were synthesized by the solution method and the solid-phase method. The synthetic peptides were examined for opioid activities on mouse vas deferens and guinea pig ileum. Among the synthetic peptides, [D-Ala^2,Leu(F_3)(2R, 4S)^5]enkephalin and [D-Ala^2,Leu(F_3)(2S, 4R)^5]enkephalin exhibited potent opioid activity, and [Leu(F_3)(2S, 4R)^5]enkephalin exhibited high δ-receptor selectivity.
- 社団法人日本薬学会の論文
- 1994-08-15
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
Tokyo College of Pharmacy
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川崎 紘一
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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前田 光子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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中尾 薫
長崎大学薬学部薬物学教室
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金戸 洋
長崎大学薬学部薬物学教室
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高橋 正克
Faculty of Pharmaceutical Sciences, Nagasaki University
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中尾 薫
Faculty of Pharmaceutical Sciences, Nagasaki University
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金戸 洋
Faculty of Pharmaceutical Sciences, Nagasaki University
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田口 武夫
Tokyo College of Pharmacy
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山本 禎洋
Daikin Industries
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下川 和弘
Daikin Industries
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高橋 正克
長崎大学薬学部医療情報・分析学教室
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小林 義郎
東京薬科大学薬学部
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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金戸 洋
Faculty Of Pharmaceutical Sciences Nagasaki University 1-14 Bunkyocho Nagasaki
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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