有機フッ素化合物の合成と反応 : 30年の研究を振り返って
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概要
- 論文の詳細を見る
This review article covers our research activities over 30 years in organofluorine chemistry. The followings are briefly summarized researches in this memorandum : (1) Trifluoromethylation of organic halides with trifluoromethyl copper complex and its application to trifluoromethylated nucleosides, (2) a systematic study on reactivity of aromatic trifluoromethyl compounds, (3) valence bond isomers of aromatic compounds stabilized by the trifluoromethyl groups, and (4) synthesis of fluorinated bioactive compounds which involve vitamin D_3,arachidonic acid and its metabolites, and retinal.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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田口 武夫
東京薬科大学薬学部
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小林 義郎
東京薬科大学薬学部
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Taguchi T
Department Of Pathobiochemistry Faculty Of Pharmacy Meijo University
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小林 義郎
東京薬科大学:ダイキン工業(株)mec研究所
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小林 義郎
東京薬科大学
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田口 武夫
東京薬科大学
関連論文
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- Effect of Chitobiose and Chitotriose on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats(Pharmacology)
- Pharmacokinetics of Chitobiose and Chitotriose Administered Intravenously or Orally to Rats(Biopharmacy)
- Antioxidant Activities of Chitobiose and Chitotriose(Miscellaneous)
- 当代留学事情
- Structure-Activity Relationship of Fluorine-Containing Renin Inhibitory Peptides Based upon the Tertiary Structure of Human Renin
- Synthesis and Biological Activity of Fluorine-Modified Platelet Activating Factors(Medicinal Chemistry,Chemical)
- PREPARATION OF (22S)- AND (22r)-24-HOMO-26,26,26,27,27,27-HEXAFLUORO-1,22,25-TRIHYDROXY-24-YNE-VITAMIN D_3
- Studies on Organic Fluorine COmpounds. IL. The Ene Reaction of Trifluoroacetone
- Studies on Organic Fluorine Compounds. XLIII. The Ene Reaction of Hexafluoroacetone
- Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
- Synthesis and Biological Activity of 1α-Fluoro-25-hydroxyvitamin D_3
- Studies on Organic Fluorind Compounds. LII : Synthesis and Biological Activity of 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxyvitamin D_3
- 大腸がんとビタミンD : 含フッ素1,25-(OH)_2D_3アナログDD-003のin vivo実験
- STEREOSELECTIVE SYNTHESIS OF TRIFLUOROMETHYLATED OLEFIN AND DIENE
- Studies on Organic Fluorine Compounds. XLVII. Synthesis of Trifluoromethylated Sugars through the Aldol Reaction of 2-Trimethylsilyloxy-4-trifluoromethylfuran
- フッ素と薬学
- Studies on Organic Fluorine Compounds. XLVI. Synthesis of 4-Trifluoromethyl-2 (5H)-furanone and 4-Trifluoromethyl-N-substituted Dihydropyrrol-2-ones
- SYNTHESIS OF TRIFLUOROMETHYLATED LACTONE AND EPOXIDE
- RADICAL CYCLIZATIONS TO FLUOROOLEFINS
- 有機フッ素化合物の合成と反応 : 30年の研究を振り返って
- Preparation and Biological Activity of 24-Epi-26,26,26,27,27,27-hexafluoro-1α, 25-dihydroxyvitamin D_2
- TRIFLUOROMETHYLATION OF CHIRAL ALDEHYDE AND SYNTHESIS OF 6-DEOXY-6,6,6-TRIFLUOROHEXOSES
- Synthesis of Fluorinated Retinal : A C_6-C_7 s-trans Fixed Retinal Containing a Trifluoromethyl Group at the Terminal Position of the Conjugated System
- TRIFLUOROMETHYLATED ALLYLIC ANION AND RADICAL : GENERATION BY THE ELECTRONIC INVERSION OF II-ALLYLICPALLADIUM COMPLEX BY SAMARIUM DIIODIDE
- オクテット
- PALLADIUM(0)-CATALYZED REACTIONS OF TRIFLUOROMETHYLATED ALLYLIC ESTER DERIVATIVES : SYNTHESIS OF TRIFLUOROMETHYLATED CHRYSANTHEMIC ACID ESTER
- ENANTIOSELECTIVE REDUCTION OF FLUOROALKYL ALKYNYL KETONES : ENORMOUS ELECTRONIC EFFECT OF THE TRIFLUOROMETHYL GROUP(Communications to the Editor)
- SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)
- KINETIC RESOLUTION OP FLUORQALKYL (E)-VINYL CARBINOL DERIVATIVES BY ASYMMETRIC EPOXIDAT1QN WITH TITANIUM-TARTRATE CATALYSTS(Communications to the Editor)
- Studies on Organic Fluorine Compounds. L. Synthesis and Biological Activity of 2α-Fluorovitamin D_3
- Studies on Organic Fluorine Compounds. XLIV. The Diels-Alder Reaction of Trifluoromethylated Cyclopropenyl Ketone and Its Imine
- フッ素薬学のこれから
- γ, γ-ジアルコキシアリルジルコニウム種を用いた炭素-炭素結合形成反応の開発
- γ,γ-ジアルコキシアリルジルコニウム種を用いた炭素-炭素結合形成反応の開発
- 雑感
- アシルジルコノセン錯体を求核的アシル基供与体とする炭素-炭素結合形成反応
- 奨励賞受賞 伊藤久央氏の業績
- フッ素系生物活性物質 : フッ素の特異性と医薬品開発
- 光学活性アトロプ異性アニリド誘導体の合成と不斉反応への応用
- 学術貢献賞受賞伊関克彦氏の業績
- ハロ環化中間体形成を活性化手法として用いる有機合成反応の開発
- フッ素置換基を有するラジカル環化系の反応
- ヨードカルボ環化反応
- ジルコノセン錯体を用いた炭素-炭素結合形成反応の新展開
- Simmons-Smith Reactions of Fluoroallyl Alcohol Derivatives
- 小林義郎先生紫綬褒章受賞
- Studies on the Organic Fluorine Compounds. XXIV. Photochemical Trifluoromethylation of Aromatic Compounds
- Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes
- 有機化合物へのフッ素導入法
- ペルフルオロアルキル芳香族の化学 (新しいフッ素化学)
- CF3基を有するヘテロ環の化学 (ヘテロ環の化学)
- STEREOSELECTIVE SYNTHESIS OF gem-BISTRIFLUOROMETHYLCYCLOPROPANE DERIVATIVES
- Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)_2
- Studies on Organic Fluorine Compounds. XL. Ring-Opening Reactions of gem-Difluorocyclopropyl Carbinols
- Studies on Organic Fluorine Compounds. XXXIX. Studies on Steroids. LXXIX. Synthesis of 1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D_3
- Synthesis and Biological Activities of Novel Antiallergic Agents with 5-Lipoxygenase Inhibiting Action.
- Synthesis of Benzimidazole Derivatives as Antiallergic Agents with 5-Lipoxygenase Inhibiting Action
- INDIUM-MEDIATED COUPLING REACTIONS OF δ-OXYGENATED ALLYL HALIDE DERIVATIVES WITH ALDEHYDES IN AQUEOUS MEDIA
- 複素5員環化合物の原子価結合異性体
- 含フッ素生理活性物質の合成
- CF3基で安定化された芳香族化合物の原子価結合異性体の化学
- ジルコノセン錯体を用いた炭素一炭素結合形成反応の新展開
- 1-PHENYLSULFONYL-3,3,3-TRIFLUOROPROPENE I : THE MICHAEL-TYPE ADDITION REACTION
- 有機フッ素化合物と生理活性
- gem-ジフルオロシクロプロパン誘導体の開環反応を用いるフルオロオフレィン類の合成 (フッ素の化学とその応用)
- ビタミンD3のフッ素による化学修飾
- オクテット
- 有機フッ素化合物の合成と反応
- 有功会員 溝口歌子先生を悼む
- 名誉会員R.B.Woodward教授を悼む
- Studies on Organic Fluorine Compounds. XXX. Ring Opening Reaction of Acetoxydifluorocyclopropanes with Various Nucleophiles
- ペルフルオルアルキル複素芳香環化合物の化学 (「フッ素化学」特集)