Synthesis and Biological Activity of 1α-Fluoro-25-hydroxyvitamin D_3
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概要
- 論文の詳細を見る
trans Diaxial opening with potassium hydrogen difluoride of the 1β, 2β-epoxy-3β-ol derived from cholenic acid gave the 1α-fluoro-2β, 3β-diol derivative. Construction of the 25-hydroxy cholesterol side chain and deoxygenation of the 2β-hydroxy group afforded 1α-fluoro-3β, 25-dihydroxycholest-5-ene, which was transformed into 1α-fluoro-25-hydroxyvitamin D_3. A single dose of 1.3μg of 1α-fluoro-25-hydroxyvitamin D_3 produced neither an intestinal calcium transport response nor a bone calcium mobilization response in vitamin D-deficient rats. In the same rats, 50ng of 25-hydroxyvitamin D_3 produced a marked response. In contrast, 1α-fluoro-25-hydroxyvitamin D_3 was 30 times more active than 25-hydroxyvitamin D_3 in binding to the chick intestinal receptor for 1α, 25-dihydroxyvitamin D_3. Addition of 1α-fluoro-25-hydroxyvitamin D_3 to human promylocytic leukemia cells resulted in strong phagocytic activity.
- 社団法人日本薬学会の論文
- 1984-09-25
著者
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高津戸 秀
上越教大
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田中 洋子
ベテランズ・アフェアーズ・メディカルセンター
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小林 義郎
Tokyo College of Pharmacy
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池川 信夫
北里大
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小林 義郎
東京薬科大学薬学部
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池川 信夫
新潟薬大
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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Deluca H
Department Of Biochemistry College Of Agricultural And Life Science University Of Wisconsin
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Deluca H
Univ. Wisconsin‐madison Wi Usa
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斎 洋之
Department Of Chemistry Tokyo Institute Of Technology
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斉 洋之
Department Of Chemistry Tokyo Institute Of Technology
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DELUCA HECTOR
Department of Chemistry, Tokyo Institute of Technology
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高津戸 秀
Department of Chemistry, Tokyo Institute of Technology
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田中 洋子
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin
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大島 悦男
Department of Chemistry, Tokyo Institute of Technology
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デルカ F.ヘクター
Department Of Biochemistry College Of Agricultural And Life Sciences University Of Wisconsin
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Deluca Hector
Department Of Biochemistry University Of Wisconsin-madison
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高津戸 秀
Department Of Chemistry Joetsu University Of Education
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大島 悦男
Department Of Chemistry Tokyo Institute Of Technology
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