Structure-Activity Relationship of Brassinosteroids with Respect to the A/B-Ring Functional Groups(Organic,Chemical)

概要

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In order to examine the biological role of the A/B-ring functional groups of plant-growth-promoting brassinosteroids, twenty-three brassinosteroids with some modifications at rings A and B (1-15 and 22-29) were bioassayed by means of the rice-lamina inclination test. The results showed that 1) removal of one or two hydroxyl groups from the A-ring reduccd the biological activity of the steroids; 2) the 7-oxalactone brassinosteroids were almost as active as the corresponding 6-oxo steroids and they were much more activc than their regioisomeric 6-oxalactone counterparts; 3) introduction of a double bond at the C-7 position and a hydroxyl group at the C-5 position of 6-oxo brassinosteroids significantly decreased the biological activity of the hormonal steroids. These data suggest that the presence of a 2α,3αdiol, 7-oxalactone or 6-oxo group, and the A/B-trans ring junction are important for high biological activity.
社団法人日本薬学会の論文
1987-01-25