Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes

スポンサーリンク

概要

• 論文の詳細を見る

• Phenyltrifluoromethylacetylene (4a) was synthesized by the pyrolysis of triphenylphosphonium α-(trifluoroacetyl) benzylide (3a), which was easily derived from benzyl halide (1a). This method can be used for the synthesis of 4-substituted-phenyltrifluoromethylacetylenes (4). The 1,3-dipolar reaction of 4 with diazomethane and phenyl azide proceeds readily to give trifluoromethylated pyrazoles and triazoles.

• 公益社団法人日本薬学会の論文
• 1984-11-25

著者

• 小林 義郎

  Tokyo College of Pharmacy

• 小林 義郎

  東京薬科大学薬学部

• 熊懐 稜丸

  Faculty of Pharmaceutical Sciences, Setsunan University

• 熊懐 稜丸

  Tokyo College of Pharmacy

• 熊懐 稜丸

  Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)tokyo College Of Pharmacy Kash

• 山下 俊範

  Tokyo College of Pharmacy

• 高橋 勝広

  Tokyo College of Pharmacy

• 黒田 尚

  Tokyo College of Pharmacy

関連論文

• Quantitative Structure-in Vivo Half-Life Relationships of Perfluorochemicals for Use as Oxygen Transporters
• Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
• 当代留学事情
• Structure-Activity Relationship of Fluorine-Containing Renin Inhibitory Peptides Based upon the Tertiary Structure of Human Renin
• Synthesis and Biological Activity of Fluorine-Modified Platelet Activating Factors(Medicinal Chemistry,Chemical)
• PREPARATION OF (22S)- AND (22r)-24-HOMO-26,26,26,27,27,27-HEXAFLUORO-1,22,25-TRIHYDROXY-24-YNE-VITAMIN D_3
• Reactions of Trifluoromethyl Ketones. VIII. Investigation of Steric Effect of a Trifluoromethyl Group through Ene Reaction of Trifluoromethyl Ketones
• Studies on Trifluoromethyl Ketones. VII. Ene Reaction of Trifluoroacetaldehyde and Its Application for Synthesis of Trifluoromethyl Compounds
• THE STERIC EFFECT OF A TRIFLUOROMETHYL GROUP
• Synthesis of Fluorine Analogues of Protoporphyrin Potentially Useful for Diagnosis and Therapy of Tumors
• Reaction of Trifluoromethyl Ketones. VI. Synthesis of Trifluorinated Analogues of Monoterpenes
• Studies on Organic Fluorine COmpounds. IL. The Ene Reaction of Trifluoroacetone
• Studies on Organic Fluorine Compounds. XLIII. The Ene Reaction of Hexafluoroacetone
• Studies on Organic Fluorine Compounds. XLI. The Friedel-Crafts Reaction of Trifluoropropene
• Synthesis and Biological Activity of 1α-Fluoro-25-hydroxyvitamin D_3
• Studies on Organic Fluorind Compounds. LII : Synthesis and Biological Activity of 26,26,26,27,27-Pentafluoro-1α-hydroxy-27-methoxyvitamin D_3
• 大腸がんとビタミンD : 含フッ素1,25-(OH)_2D_3アナログDD-003のin vivo実験
• Studies on Organic Fluorine Compounds. II. Mass Spectrometry of Trifluoromethylated Pyridines.
• Syntheses of Ten-membered Ring Amine Derivatives and 1-Azabicyclo-[4,4,1] undecane from 3,4,6,7,8,9-Hexahydro-2H-quinolizine
• Studies on the Reaction of Heterocyclic Compounds. XV. N-Alkylation of 1,2,3,4-Tetrahydro-5-methyl-1,6-naphthyridine
• Studies on the Reactions of Heterocyclic Compounds. XIV. 1,3-dipolar Cycloaddition of Some Isoquinolinium Ylides with Methyl Propiolate
• STEREOSELECTIVE SYNTHESIS OF TRIFLUOROMETHYLATED OLEFIN AND DIENE
• Studies on Organic Fluorine Compounds. XLVII. Synthesis of Trifluoromethylated Sugars through the Aldol Reaction of 2-Trimethylsilyloxy-4-trifluoromethylfuran
• Studies on Organic Fluorine Compounds. VII. Trifluoromethylation of Aromatic Compounds
• Studies on Organic Fluorine Compounds. XLVI. Synthesis of 4-Trifluoromethyl-2 (5H)-furanone and 4-Trifluoromethyl-N-substituted Dihydropyrrol-2-ones
• Studies on Organic Fluorine Compounds. XLV. Synthesis and Regioselective Substitution Reaction of 3-Trifluoromethylfuran
• SYNTHESIS OF TRIFLUOROMETHYLATED LACTONE AND EPOXIDE
• 有機フッ素化合物の合成と反応 : 30年の研究を振り返って
• Preparation and Biological Activity of 24-Epi-26,26,26,27,27,27-hexafluoro-1α, 25-dihydroxyvitamin D_2
• TRIFLUOROMETHYLATION OF CHIRAL ALDEHYDE AND SYNTHESIS OF 6-DEOXY-6,6,6-TRIFLUOROHEXOSES
• Synthesis of Fluorinated Retinal : A C_6-C_7 s-trans Fixed Retinal Containing a Trifluoromethyl Group at the Terminal Position of the Conjugated System
• TRIFLUOROMETHYLATED ALLYLIC ANION AND RADICAL : GENERATION BY THE ELECTRONIC INVERSION OF II-ALLYLICPALLADIUM COMPLEX BY SAMARIUM DIIODIDE
• オクテット
• PALLADIUM(0)-CATALYZED REACTIONS OF TRIFLUOROMETHYLATED ALLYLIC ESTER DERIVATIVES : SYNTHESIS OF TRIFLUOROMETHYLATED CHRYSANTHEMIC ACID ESTER
• ENANTIOSELECTIVE REDUCTION OF FLUOROALKYL ALKYNYL KETONES : ENORMOUS ELECTRONIC EFFECT OF THE TRIFLUOROMETHYL GROUP(Communications to the Editor)
• SYNTHESIS OF 5-FLUOROARACHIDONIC ACID AND ITS BIOTRANSFORMATION TO 5-FLUORO-12-HYDROXYEICOSATETRAENOIC ACID(Communications to the Editor)
• KINETIC RESOLUTION OP FLUORQALKYL (E)-VINYL CARBINOL DERIVATIVES BY ASYMMETRIC EPOXIDAT1QN WITH TITANIUM-TARTRATE CATALYSTS(Communications to the Editor)
• Studies on Organic Fluorine Compounds. L. Synthesis and Biological Activity of 2α-Fluorovitamin D_3
• Trifluoromethylation with Bromotrifluoromethane
• Studies on Organic Fluorine Compounds. XLIV. The Diels-Alder Reaction of Trifluoromethylated Cyclopropenyl Ketone and Its Imine
• フッ素薬学のこれから
• Studies on the Organic Fluorine Compounds. XXIV. Photochemical Trifluoromethylation of Aromatic Compounds
• Studies on Organic Fluorine Compounds. XXI. Isomerization of Fluorinated Dewar Pyridine Derivative and Its Metal Complexes
• Studies on Organic Fluorine Compounds. XX. Synthesis and Reactions of a Substituted Dewar Pyridine
• Studies on Organic Fluorine Compounds. XIX. Synthesis and Reactions of"Dewar"Thiophene
• Studies on Organic Fluorine Compounds. XVI. : Stereochemistry in Fluorination of Sterols with Phenylfluorophosphoranes
• Studies on Organic Fluorine Compounds. XIII. Studies on Equilibrium of (Trifluoro- and/or Chlorodifluoromethyl)-dihydro-s-triazine Derivatives by ^F-Nuclear Magnetic Resonance Spectra
• Studies on Organic Fluorine Compounds. XII. Photolysis of (Fluoroalkyl)-s-triazines
• Studies on Organic Fluorine Compounds. XI. Reaction of Arylfluorophosphoranes with Alcohols
• Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes
• 有機化合物へのフッ素導入法
• ペルフルオロアルキル芳香族の化学 (新しいフッ素化学)
• CF3基を有するヘテロ環の化学 (ヘテロ環の化学)
• Studies on Organic Fluorine Compounds. XXII. Synthesis and Reactions of (Trifluoromethyl) benzofurans
• Studies on Organic Fluorine Compounds. XVIII. On the Mechanism of the Conversion of Trifluoromethyl Group to Amino Group on a Quinoline Ring
• Studies on Organic Fluorine Compounds. XVII. Reaction of Benzotrifluoride Derivatives with Sodium Amide
• Studies on the Reactions of Heterocyclic Compounds. XIII. Basicity of 1,6-Naphthyridine and Its N-Oxides : Correlation to Peracid Oxidation
• Studies on the Reaction of Heterocyclic Compounds. XII. N-Oxidation of Diazabenzene and Diazanaphthalene
• Photolysis of 2-(Trifluoromethyl) quinoline 1-Oxides and 1-(Trifluoromethyl) isoquinoline 2-Oxide
• Synthese von Derivaten der Cinchona-Alkaloide. XXXIII. Synthese von 2'-Cyanoderivaten der Alkaloide der Chinin-Reihe
• Studies on the Reactions of Heterocyclic Compounds. X. 1,3-Dipolar Cycloaddition Reaction of Isoquinolinium Ylides and Dicyanoacetylene
• Studies on the Reactions of Heterocyclic Compounds. IX. Syntheses of 1,10b-Dihydropyrrolo[2,1-α]isoquinolines and 2,3-Dihydropyrrolo[2,1-α]isoquinolines
• Studies on the Reactions of Heterocyclic Compounds. VI. 1,3-Dipolar Cycloaddition Reaction of Disubstituted Methylides of Isoquinoline and Pyridine with Acetylenic Compounds
• Studies on the Reactions of Heterocyclic Compounds. VIII. 1,3-Dipolar Cycloaddition Reaction of Isoquinolinium Cyano (methoxycarbonyl)-methylide with Dimethyl Acetylenedicarboxylate : Structure and Reaction of the Adduct
• STEREOSELECTIVE SYNTHESIS OF gem-BISTRIFLUOROMETHYLCYCLOPROPANE DERIVATIVES
• Studies on Organic Fluorine Compounds. XXXI. Oxidative Coupling of Ketone Enolates and Trimethylsilyl Enol Ethers by Means of Cu(OTf)_2
• Studies on Organic Fluorine Compounds. IV. Conversion of Alcohols to Fluorides by Diphenyltrifluorophosphorane
• Studies on Organic Fluorine Compounds. III. Conversion of Alcohols to Fluorides by Difluorotriphenylphosphorane
• Studies on Organic Fluorine Compounds. LIV. : Synthesis of 2,2-Difluoroarachidonic Acid
• Studies on Organic Fluorine Compounds. XL. Ring-Opening Reactions of gem-Difluorocyclopropyl Carbinols
• Studies on Organic Fluorine Compounds. XXXIX. Studies on Steroids. LXXIX. Synthesis of 1α, 25-Dihydroxy-26,26,26,27,27,27-hexafluorovitamin D_3
• Studies on the Reactions of Heterocyclic Compounds. XI. Methylation of Heteroaromatic N-Oxides
• Oxidative Cyanation of Aromatic Amine Oxides
• Studies on the Reactions of Heterocyclic Compounds. III. Cyanation of 1,6-Naphthyridine N-Oxides
• Studies on the Reactions of Heterocyclic Compounds. I. Syntheses and Some Reactions of 1,6-Naphthyridine N-Oxides
• Studies on the Reactions of Heterocyclic Compounds. V. Syntheses of Diazinium Ylides and Their Conversion to Azaindolizines
• Studies on the Reactions of Heterocyclic Compounds. IV. Preparations and Reactions of Heterocyclic N-Ylides
• 7.規那塩基の変換
• 複素5員環化合物の原子価結合異性体
• 含フッ素生理活性物質の合成
• CF3基で安定化された芳香族化合物の原子価結合異性体の化学
• Studies on Organic Fluorine Compounds. X. Reaction of Trifluoromethyl Group in Heterocycles with Sodium Amide
• 1-PHENYLSULFONYL-3,3,3-TRIFLUOROPROPENE I : THE MICHAEL-TYPE ADDITION REACTION
• ビタミンD3のフッ素による化学修飾
• Studies on the Reactions of Heterocyclic Compounds. II. Syntheses and Some Reactions of 1,6-Phenanthroline N-Oxides
• オクテット
• 有機フッ素化合物の合成と反応
• 有功会員 溝口歌子先生を悼む
• 名誉会員R.B.Woodward教授を悼む
• Studies on organic fluorine compounds.-1,2-
• Synthese von Derivaten der Cinchona-Alkaloide. XXX. Ableitung einer Verbindung mit dem Tetrahydro-β-carbolin-Ring aus Chinin.
• Synthese von Derivaten der Cinchona-Alkaloide. XXIX. Uber Dihydroepinichin und seine Acylwanderung.
• Ableitung einer Verbindung mit dem Tetrahydro-β-carbolin-Ring aus Chinin
• Synthese von Derivaten der Cinchona-Alkaloide. XXVIII. Synthese von 2'-Hydroxydihydronichin.
• Studies on the Organic Fluorine Compounds. IX. Reactions of (Trifluoromethyl) quinolines with Metal Hydrides
• Studies on Organic Fluorine Compounds. VIII. Alcoholysis of (Trifluoromethyl) quinolines
• Studies on Organic Fluorine Compounds. VI. Preparations and Reactions of (Trifluoromethyl) quinoline N-Oxides
• Studies on Organic Fluorine Compounds. XXX. Ring Opening Reaction of Acetoxydifluorocyclopropanes with Various Nucleophiles
• Studies on Organic Flourine Compounds. V. Preparations and Reactions of N-Oxides of Trifluoromethylated Pyridines
• SYNTHESES OF β, β-DIFLUOROCARBOXYLIC ACID DERIVATIVES THROUGH THE CLAISEN REARRANGEMENT OF 1,1-DIFLUORO-1-ALKEN-3-OLS

もっと見る 閉じる

スポンサーリンク