Reactions of Trifluoromethyl Ketones. VIII. Investigation of Steric Effect of a Trifluoromethyl Group through Ene Reaction of Trifluoromethyl Ketones

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概要

• 論文の詳細を見る

• In the course of our study on the ene reaction of trifluoromethyl ketones, a trifluoromethyl group has been observed to behave as a larger substituent than commonly believed in the biomedicinal field. To estimate the steric effect of a trifluoromethyl group, we synthesized several trifluoromethyl ketones (RCOCF)_3 and examined in detail their ene reaction with cyclohexene, a 1,2-disubstituted ene having the least steric requirement. In this reaction, a trifluoromethyl group was found to behave as if it were a much larger substituent than a phynyl or isobutyl group and as large as a sec-butyl group.

• 社団法人日本薬学会の論文
• 1992-03-25

著者

• 三木 卓一

  Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University

• 熊懐 稜丸

  摂南大・薬

• 永井 隆文

  Faculty Of Pharmaceutical Sciences Setsunan University

• 西岡 吾朗

  Faculty of Pharmaceutical Sciences, Setsunan University

• 小山 まゆみ

  Faculty of Pharmaceutical Sciences, Setsunan University

• 安藤 章

  Faculty of Pharmaceutical Sciences, Setsunan University

• 三木 卓一

  Faculty of Pharmaceutical Sciences, Setsunan University

• 熊懐 稜丸

  Faculty of Pharmaceutical Sciences, Setsunan University

• Ando A

  Faculty Of Pharmaceutical Sciences Setsunan University

• 西岡 吾朗

  Faculty Of Pharmaceutical Sciences Setsunan University

• 熊懐 稜丸

  摂南大薬

• 熊懐 稜丸

  Faculty Of Pharmaceutical Sciences Setsunan University

• 熊懐 稜丸

  Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)tokyo College Of Pharmacy Kash

• 三木 卓一

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

• 三木 卓一

  武田薬品工業株式会社研究開発本部

• 小山 まゆみ

  Faculty Of Pharmaceutical Sciences Setsunan University

• Miki Takuichi

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

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