New Approach to a Novel Axially Chiral Ligand Showing Spontaneous Enrichment of Axial Chirality
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概要
- 論文の詳細を見る
We have synthesized novel axially chiral ligand with two chiral centers, (R)-(R)_2- and (S)-(S)_2-2, 2'-bis(2, 2, 2-trifluoro-l-hydroxyethyl)biphenyl (1), which showed a high asymmetric induction when used as ligand. Here, another new approach to 1 by kinetic and thermodynamic resolution is presented which gave these ligands in a much shorter steps, in a higher yield, and in a higher enantiomeric excess.
- 公益社団法人日本薬学会の論文
- 2003-03-01
著者
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安藤 章
Faculty of Pharmaceutical Sciences, Setsunan University
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Ando A
Faculty Of Pharmaceutical Sciences Setsunan University
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Sato K
National Inst. Health Sci. Tokyo Jpn
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OMOTE Masaaki
Faculty of Pharmaceutical Sciences
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ANDO Akira
Faculty of Pharmaceutical Sciences
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KUMADAKI Itsumaro
Faculty of Pharmaceutical Sciences
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SATO Kazuyuki
Faculty of Pharmaceutical Sciences, Setsunan University
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Hisayama T
Univ. Tokushima School Of Medicine Tokushima Jpn
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HASEGAWA Tomokuni
Faculty of Pharmaceutical Sciences
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Omote M
Faculty Of Pharmaceutical Sciences Setsunan University
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Kumadaki I
Faculty Of Pharmaceutical Sciences Setsunan University
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