Synthesis of Fluorine Analogues of Protoporphyrin Potentially Useful for Diagnosis and Therapy of Tumors

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概要

• 論文の詳細を見る

• With the aim of obtaining a porphyrin derivative useful for diagnosis and therapy of cancer, fluorine analogues of protoporphyrin, in which the vinyl group(s) were replaced by difluorovinyl group(s), were synthesized by the reaction of the formylporphyrins with sodium chlorodifluoroacetate in the presence of triphenylphosphine. Some improvements in the reported procedures for the synthesis of formylporphyrins are also described. Preliminary results of biological tests of the products showed that 8^2,8^2-difluoroprotoporphyrin accumulates to gastric cancer more selectively than other fluorine analogues and that 3^2,3^2,8^2,8^2-tetrafluoroprotoporphyrin is taken up by rat hepatoma cells more readily than the others.

• 社団法人日本薬学会の論文
• 1990-08-25

著者

• 三木 卓一

  Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University

• 熊懐 稜丸

  摂南大・薬

• 永井 隆文

  Faculty Of Pharmaceutical Sciences Setsunan University

• 小山 まゆみ

  Faculty of Pharmaceutical Sciences, Setsunan University

• 安藤 章

  Faculty of Pharmaceutical Sciences, Setsunan University

• 三木 卓一

  Faculty of Pharmaceutical Sciences, Setsunan University

• 熊懐 稜丸

  Faculty of Pharmaceutical Sciences, Setsunan University

• 品田 哲郎

  Faculty of Pharmaceutical Sciences, Setsunan University

• 木下 進司

  Faculty of Pharmaceutical Sciences, Setsunan University

• 有村 典子

  Faculty of Pharmaceutical Sciences, Setsunan University

• 佐藤 治男

  Sato Pharmaceutical Research Institute, Inc.,

• 佐藤 治男

  Sato Institute Of Pharmaceutical Sciences

• Ando A

  Faculty Of Pharmaceutical Sciences Setsunan University

• SATO Hiromi

  Tohoku College of Pharmacy

• Sato H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• 熊懐 稜丸

  摂南大薬

• 熊懐 稜丸

  Faculty Of Pharmaceutical Sciences Setsunan University

• 熊懐 稜丸

  Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)tokyo College Of Pharmacy Kash

• 木下 進司

  Faculty Of Pharmaceutical Sciences Setsunan University

• 品田 哲郎

  Kobe Women's College Of Pharmacy

• 三木 卓一

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

• 三木 卓一

  武田薬品工業株式会社研究開発本部

• 小山 まゆみ

  Faculty Of Pharmaceutical Sciences Setsunan University

• 有村 典子

  Faculty Of Pharmaceutical Sciences Setsunan University

• Miki Takuichi

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

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