Studies on the Diels-Alder Reaction of 5-Ethoxy-4-ethoxycarbonylmethyloxazole
スポンサーリンク
概要
- 論文の詳細を見る
The Diels-Alder reaction of 5-ethoxy-4-ethoxycarbonylmethyloxazole (I) with dienophiles was investigated. The stereochemistry of the addition products that had an exocyclic double bond was confirmed by the spectroscopic data. The reaction of I with maleic anhydride gave endo- (II) and exo-adduct (III), and the isomerization of II to III proceeded easily. The reaction of I with eight symmetrical dienophiles afforded the isomeric adducts. Similar treatment of asymmetrical dienophiles afforded the corre-sponding adducts, respectively. The stereochemistry of these adducts was discussed.
- 公益社団法人日本薬学会の論文
- 1972-04-25
著者
-
三木 卓一
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
-
松尾 泰介
Central Research Division, Takeda Chemical Industries, Ltd.
-
三木 卓一
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
-
三木 卓一
Research Laboratories, Takeda Chemical Industries, Ltd.
-
三木 卓一
武田薬品工業株式会社研究開発本部
-
松尾 泰介
Research & Development Division, Takeda Chemical Industries, Ltd.
-
Miki Takuichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
関連論文
- Partial Purification and Substrate Specificity of Flavin-Containing Monooxygenase from Rat Brain Microsomes
- Synthesis of Carumonam (AMA-1080) and a Related Compound Starting from (2R, 3R)-Epoxysuccinic Acid
- Chemical Modification of Sulfazecin. Synthesis of 4-Methoxycarbonyl-2-azetidinone-1-sulfonic Acid Derivatives
- Reactions of Trifluoromethyl Ketones. VIII. Investigation of Steric Effect of a Trifluoromethyl Group through Ene Reaction of Trifluoromethyl Ketones
- Studies on Trifluoromethyl Ketones. VII. Ene Reaction of Trifluoroacetaldehyde and Its Application for Synthesis of Trifluoromethyl Compounds
- THE STERIC EFFECT OF A TRIFLUOROMETHYL GROUP
- Synthesis of Fluorine Analogues of Protoporphyrin Potentially Useful for Diagnosis and Therapy of Tumors
- Reaction of Trifluoromethyl Ketones. VI. Synthesis of Trifluorinated Analogues of Monoterpenes
- Reaction of Trifluoromethyl Ketones. V. : Dehydration of Trifluoromethylated Homoallyl Alcohols : Synthesis of Trifluoromethylated Dienes
- SYNTHESIS OF 9,9,9-TRIFLUORO-2-p-MENTHENE-1,8-DIOL. DETERMINATION OF THE STRUCTURE BY X-RAY ANALYSIS
- Synthesis of Fluorine Analogues of Vitamin E. II. : Synthesis of 2-(3-Chloropropyl)-2,5,7,8-tetramethyl-6-chromanol and Its Application for Stereocontrolled Witting Reaction with Trifluoromethyl Ketones
- Synthesis of Fluorine Analogues of Vitamin E
- Studies on Organic Fluorine COmpounds. IL. The Ene Reaction of Trifluoroacetone
- ENE REACTION OF N-TOSYLHEXAFLUOROACETONE IMINE
- An Improved Synthesis of N-Hydroxyamino Acids and Their Esters Using (Z)-2-Furaldehyde Oxime
- Synthesis of Polyhydroxysteroids. IV. Syntheses of Pregnanetetrols. (2).
- Synthesis of Polyhydroxysteroids. III. Synthesis of Pregnanetetrols. (1).
- Synthesis of Polyhydroxysteroids. I. A Modified Degradation of the Diosgenin Side Chain.
- Studies on Ethylenic Compounds. III. Hydrazone-type Derivatives of Vitamin A Aldehyde.
- △^-3-Ketosteroidの合成法
- エチレン化合物の研究(第2報)IononeのAllene型異性体の合成
- エチレン化合物の研究(第1報)Dihydroionone新異性体の合成
- Synthesis of Polyhydroxysteroids. V. Preparation and Infrared Spectra of 16β, 20α-Isopropylidenedioxysteroids.
- Synthesis of Polyhydroxy-steroids. II. Syntheses of Isomeric 5α-Pregnane-3,5,6,16,20-pentols and Related Compounds.
- Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C_3-Position. I. Synthesis of 3-(5-Substituted-1,3,4-thiadiazol-2-yl) ceph-3-em Derivatives
- Synthesis of 3-Carboxyceph-3-em Compounds and Reactions of Cephalosporin Thiolactones
- Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C_3-Position
- Dimethyl 5-Hydroxy-6-methylcinchomeronateからPyrido [3,4-d]-pyridazineおよびα-Styrylpyridazine誘導体の合成
- Studies on the Diels-Alder Reaction of 4-Carboxymethyl-5-ethoxyoxazole
- Studies on the Diels-Alder Reaction of 5-Ethoxy-4-ethoxycarbonylmethyloxazole
- ビタミンB_6同族体の合成
- Further Studies on the Velocity of Diels-Alder Reaction
- ビタミンB_6の新合成法
- Quinol類に関する知見(第3報)2-Oxo-8,10-dihydroxy-△^-hexahydronaphthy1-7-acetic Acid Lactoneの転位
- Synthesis and Antibacterial Activity of 3-Acylamino-3-methoxy-2-azetidinone-1-sulfonic Acid Derivatives
- Synthesis and Antibacterial Activity of 3-Acylamino-2-azetidinone-1-sulfonic Acid Derivatives
- A New Synthetic Method of 3-Formylcephalosporins