Studies on Ethylenic Compounds. III. Hydrazone-type Derivatives of Vitamin A Aldehyde.
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概要
- 論文の詳細を見る
It was found that the crystalline derivatives were readily obtainable when various hydrazine compounds were reacted with retinal. Many hydrazone-type derivatives of retinal were prepared and their physical properties, stability, toxicity and biopotency were examined. All such derivatives are more stable than vitamin A palmitate, their toxicity being low, and some of them showed considerably higher vitamin A activity. Retinal azine is obtained as crystals of m. p. 189° in a good yield when retinal is reacted with hydrazine-hydrate in the presence of an organic acid as a promotor. This compound is expected to have higher biological activity. p-Aminobenzoylhydrazone of retinal showed the biopotency equivalent to that of vitamin A.
- 公益社団法人日本薬学会の論文
- 1962-10-25
著者
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三木 卓一
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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三木 卓一
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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三木 卓一
Research Laboratories, Takeda Chemical Industries, Ltd.
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原 雄次郎
Research Laboratories, Takeda Chemical Industries, Ltd.
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三木 卓一
武田薬品工業株式会社研究開発本部
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Miki Takuichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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原 雄次郎
Research Laboratories Takeda Chemical Industries Ltd.
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