Synthesis of Fluorine Analogues of Vitamin E

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概要

• 論文の詳細を見る

• As part of a search for biologically active analogues of vitamin E, fluorine derivatives of tocotrienol and related compounds were synthesized by the ring-closure of trifluoroprenols with trimethylhydroquinone. For this purpose, the trifluoroprenols were synthesized by the Wittitg-Horner reaction of trifluoroacetone or its prenyl homologues with triethylphosphonoacetate followed by reduction of the trifluoromethylated acrylic ester derivatives. Although 4,4,4-trifluoroprenol itself did not react with the hydroquinone, 7,7,7-trifluorodiprenol and higher prenols gave 6-chromanols with a trifluofomethylated side-chan.

• 社団法人日本薬学会の論文
• 1988-02-25

著者

• 三木 卓一

  Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University

• 熊懐 稜丸

  摂南大・薬

• 永井 隆文

  Faculty Of Pharmaceutical Sciences Setsunan University

• 小山 まゆみ

  Faculty of Pharmaceutical Sciences, Setsunan University

• 安藤 章

  Faculty of Pharmaceutical Sciences, Setsunan University

• 三木 卓一

  Faculty of Pharmaceutical Sciences, Setsunan University

• 熊懐 稜丸

  Faculty of Pharmaceutical Sciences, Setsunan University

• 田村 美穂子

  Faculty of Pharmaceutical Sciences, Setsunan University

• Ando A

  Faculty Of Pharmaceutical Sciences Setsunan University

• 熊懐 稜丸

  摂南大薬

• 熊懐 稜丸

  Faculty Of Pharmaceutical Sciences Setsunan University

• 熊懐 稜丸

  Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)tokyo College Of Pharmacy Kash

• 田村 美穂子

  Faculty Of Pharmaceutical Sciences Setsunan University

• 三木 卓一

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

• 三木 卓一

  武田薬品工業株式会社研究開発本部

• 小山 まゆみ

  Faculty Of Pharmaceutical Sciences Setsunan University

• Miki Takuichi

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

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