Synthesis of Polyhydroxysteroids. I. A Modified Degradation of the Diosgenin Side Chain.
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概要
- 論文の詳細を見る
Chlorination of diosgenin acetate followed by treatment with performic acid, dechlorination, and hydrolysis has given pregn-5-ene-3β, 16β, 20α-triol in 60〜70% overall yield. When the chlorination was conducted in a dimethylformamide solution, the main product was 3β-acetoxy-5-chloro-6β-formyloxy-5α, 25D-spirostan. Validity of this novel reaction was confirmed by expriments in the cholesterol series. Synthesis of 9α-chloro-11β-formyloxysteroids from ⊿^<9(11)>-steroids has also been facilitated.
- 公益社団法人日本薬学会の論文
- 1963-01-25
著者
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三木 卓一
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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野口 俊作
Central Research Division Takeda Chemical Industries Ltd.
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野口 俊作
Research Laboratories, Takeda Chemical Industries, Ltd.
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森田 桂
Research Laboratories, Takeda Chemical Industries, Ltd.
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河野 海
Research Laboratories Takeda Chemical Industries Ltd.
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野口 俊作
Research Laboratories Takeda Chemical Industries Ltd.
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森田 桂
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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三木 卓一
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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三木 卓一
Research Laboratories, Takeda Chemical Industries, Ltd.
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森田 桂
Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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三木 卓一
武田薬品工業株式会社研究開発本部
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森田 桂
Research And Development Division Takeda Chemical Industries Ltd.
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Miki Takuichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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