1-Indancarboxylic Acids. II. Synthesis of 4- and 6-Aroyl-1-indan-carboxylic Acids as Potential Antiinflammatory Agents

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概要

• 論文の詳細を見る

• 6-Aroyl-1-indancarboxylic acids (V) and isomeric 4-aroyl-1-indancarboxylic acids (XVIII) were prepared in an attempt to obtain information on the receptor sites of anti-inflammatory aroylarylacetic acids. Compounds V were easily obtained by the Friedel-Crafts reaction of ethyl 1-indancarboxylate (III) and aroyl chloride. On the other hand, compounds XVIII were synthesized from 1-oxo-4-indancarboxylic acid (VIII) via the Friedel-Crafts reaction of 1-cyano-4-indancarbonyl chloride (XVI) and benzene or its derivative. Although compounds XVIII showed potent antiinflammatory activity, the activity of V was significantly weaker. The result suggests that locations and conformations of the functional groups in XVIII are considerably close to the actual conformation of a aroylarylacetic acid required for exerting antiinflammatory activity.

• 社団法人日本薬学会の論文
• 1978-04-25

著者

• 青野 哲也

  Resarch & Development Division Takeda Chemical Industries Ltd.

• 青野 哲也

  Central Research Division, Takeda Chemical Industries, Ltd.

• 今西 正之

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division, Takeda Chemical Industries, Ltd.

• 荒木 義昭

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division Takeda Chemical Industries Ltd.

• 今西 正之

  Central Research Division Takeda Chemical Industries Ltd.

• 荒木 義昭

  Central Research Division Takeda Chemical Industries Ltd.

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