Steroid [16,17-c]isoxazoline

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概要

• 論文の詳細を見る

• 5'-Methyl-5α-androstano[16,17-c]isoxazolin-3β-ol (Va) and 5'-methylandrost-5-eno[16,17-c]isoxazolin-3β-ol (Vb), were obtained by treatment of 3β, 20α-dihydroxy-5α-pregnan-16-one 3-acetate 16-oxime (IIIa) or 3β, 20α-dihydroxypregn-5-en-16-one 3-acetate 16-oxime (IIIb) with tosyl chloride in pyridine followed by alkaline hydrolysis. Oxidation of Va and Vb gave the corresponding 3-oxo-compounds, VIa and VIb. VIb was further isomerized to 5'-methylandrost-4-eno[16,17-c]isoxazolin-3-one (VIIb).

• 社団法人日本薬学会の論文
• 1964-10-25

著者

• 今西 正之

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division Takeda Chemical Industries Ltd.

• 今西 正之

  Central Research Division Takeda Chemical Industries Ltd.

• 野口 俊作

  Research Laboratories, Takeda Chemical Industries, Ltd.

• 今西 正之

  Research Laboratories, Takeda Chemical Industries, Ltd.

• 森田 桂

  Research Laboratories, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Research Laboratories Takeda Chemical Industries Ltd.

• 森田 桂

  Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

• 森田 桂

  Chemical Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.

• 森田 桂

  Research And Development Division Takeda Chemical Industries Ltd.

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