1-Indancarboxylic Acids. III. Chemical Modifications of Antiinflammatory 4-Aroyl-1-indancarboxylic Acids

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概要

• 論文の詳細を見る

• For elucidating the receptor site of antiinflammatory arylacetic acids, some modifications were made on 4-aroyl-1-indancarboxylic acids (Ia-d) which have potent antiinflammatory activities. Modifications were introduced on the characteristic parts of I and 1-methylated derivatives (VIII), tetralin analogs (XVIII) and benzyl analogs (XXX) of I were prepared. However, these compounds showed weaker activities than the parent compound I. The result suggests that 1-indancarboxylic acid is the pharmacologically effective derivative of arylacetic acid.

• 社団法人日本薬学会の論文
• 1978-05-25

著者

• 青野 哲也

  Resarch & Development Division Takeda Chemical Industries Ltd.

• 青野 哲也

  Central Research Division, Takeda Chemical Industries, Ltd.

• 今西 正之

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division, Takeda Chemical Industries, Ltd.

• 荒木 義昭

  Central Research Division, Takeda Chemical Industries, Ltd.

• 田中 邦大

  Central Research Division, Takeda Chemical Industries, Ltd.

• 野口 俊作

  Central Research Division Takeda Chemical Industries Ltd.

• 今西 正之

  Central Research Division Takeda Chemical Industries Ltd.

• 荒木 義昭

  Central Research Division Takeda Chemical Industries Ltd.

• 田中 邦大

  Central Research Division Takeda Chemical Industries Ltd.

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