1-Indancarboxylic Acids. I. Electrophilic Substitution Reactions of 1-Indancarboxylic Acid and Synthesis of 6-Substituted 1-Indancarboxylic Acids as Potential Antiinflammatory Agents
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概要
- 論文の詳細を見る
The relative reactivity in each position of 1-indancarboxylic acid (IV) toward electro-hilic substitution reaction such as chlorination, bromination, acylation, sulfonation and nitration was examined and it was found that the 6-position is the most reactive. By these reactions, pharmacologically interesting meta-substituted phenylacetic acid derivatives were readily obtained. Electrophilic chlorination of IV followed by cycloalkylation provided an improved alternative synthetic method of antiinflammatory 6-chloro-5-cyclohexyl-1-indancarboxylic acid (TAI-284,I) and its analogs.
- 社団法人日本薬学会の論文
- 1977-12-25
著者
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青野 哲也
Resarch & Development Division Takeda Chemical Industries Ltd.
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岸本 彰二
Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.
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岸本 彰二
Central Research Division, Takeda Chemical Industries, Ltd.
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青野 哲也
Central Research Division, Takeda Chemical Industries, Ltd.
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野口 俊作
Central Research Division, Takeda Chemical Industries, Ltd.
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荒木 義昭
Central Research Division, Takeda Chemical Industries, Ltd.
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野口 俊作
Central Research Division Takeda Chemical Industries Ltd.
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岸本 彰二
Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries
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荒木 義昭
Central Research Division Takeda Chemical Industries Ltd.
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