Chemical Modification of Fumagillin. I. 6-O-Acyl, 6-O-Sulfonyl, 6-O-Alkyl, and 6-O-(N-Substituted-carbamoyl)fumagillols

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概要

• 論文の詳細を見る

• The hydroxy group of fumagillol (3), a degradation product of fumagillin (1), was acylated, sulfonylated, alkylated or carbamoylated, and the anti-angiogenic activity of the resulting products was examined. These compounds inhibited the angiogenesis induced by basic fibroblast growth factor in the rat corneal micropocket assay and the growth of vascular endothelial cells in vitro. Among them, compound 2 (AGM-1470) was found to show the most potent inhibitory effect on the growth of vascular endothelial cells and was selected form this series as a candidate for further development.

• 社団法人日本薬学会の論文
• 1992-01-25

著者

• 須藤 勝一

  Pharmaceutical Research Laboratories III, Takeda Chemical Industries, Ltd.,

• 岸本 彰二

  Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.

• 香西 義雄

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 岸本 彰二

  Chemistry Research Laboratories, Takeda Chemical Industries, Ltd.

• [マル]井 省吾

  Chemistry Research Laboratories, Takeda Chemical Industries

• 伊藤 文雄

  Chemistry Research Laboratories, Takeda Chemical Industries

• 香西 義雄

  Biology Research Laboratories, Takeda Chemical Industries

• 須藤 勝一

  Biology Research Laboratories, Takeda Chemical Industries

• 岸本 彰二

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 伊藤 文雄

  Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.

• 須藤 勝一

  Pharmaceutical Research Laboratories Iii Takeda Chemical Industries Ltd.

• 井 省吾

  Chemistry Research Laboratories Takeda Chemical Industries

• 香西 義雄

  Biology Research Laboratories Takeda Chemical Industries

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