Chemistry and Anti-tumor Activity of Sperabillin Polymers
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概要
- 論文の詳細を見る
Sperabillin A, 3-[[(3R, 5R)-3-amino-6-[(2E, 4Z)-2,4-hexadienoylamino]-5-hydroxyhexanoyl]amino]propanamidine dihydrochloride, was polymerized on standing for several days under a highly humid atmosphere or in the presence of radical initiators. The average molecular weight of the polymers obtained could be regulated by changing the reaction conditions in the latter case. Spectral analyses of the polymers revealed that the 2,4-hexadienoyl moiety of sperabillins was polymerized in a free radical-initiated reaction. The polymers selectively inhibited the proliferation of human umbilical vein endothelial (HUVE) cells. Polymers having higher molecular weight showed stronger inhibition of HUVE cell proliferation. In addition, the polymers showed anti-tumor activity against B16 melanoma in vivo.
- 社団法人日本薬学会の論文
- 1993-05-15
著者
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堀 晃
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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香西 義雄
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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夏苅 英昭
Pharmaceutical Research Laboratories II, Pharmaceutical Research Division, Takeda Chemical Industrie
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飛田 恒明
Discovery Research Division Takeda Chemical Industries, Ltd.,
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坪谷 重利
Discovery Research Division Takeda Chemical Industries, Ltd.,
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村上 守生
Pharmaceutical Research Division Takeda Chemical Industries, Ltd.,
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原田 節夫
Discovery Research Division Takeda Chemical Industries, Ltd.,
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夏苅 英昭
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
-
原田 節夫
Discovery Research Division Takeda Chemical Industries Ltd.
-
飛田 恒明
Discovery Research Division Takeda Chemical Industries Ltd.
-
坪谷 重利
Discovery Research Division Takeda Chemical Industries Ltd.
-
村上 守生
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
-
香西 義雄
Pharmaceutical Research Division Takeda Chemical Industries, Ltd.,
-
夏苅 英昭
Pharmaceutical Research Division Takeda Chemical Industries, Ltd.,
-
堀 晃
Pharmaceutical Research Division Takeda Chemical Industries, Ltd.,
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