Heterocycles. IV. Reactions of 2-Amino-3H-1,4-benzodiazepines with Primary Amines and Hydroxylamines
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概要
- 論文の詳細を見る
Substitution of the amino group of 2-amino-3H-1,4-benzodiazepines such as 1 and 2 with primary amines and hydroxylamines was investigated and the 2-substituted compounds 3-19,21 and 37 were synthesized as shown in Table I. In the case of the reaction with hydroxylamine, however, a 2-aminomethylquinazoline 3-oxide (20) was obtained from a 2-amino-and a 2-methylamino-benzodiazepines (1 and 3) in addition to 2-hydroxyamino-1,4-benzodiazepine (21). This data show that ring opening at the N-4 : C-5 double bond occurred. A similar ring opening in a 2-methylamino-1,4-benzodiazepine 4-oxide (4) furnished a quinazoline-2-carboxaldehyde oxime 3-oxide (40). The derivatives of 21 and its oxide (37) were prepared as exemplified by the synthesis of oxadiazolo [4,3-a] [1,4]-benzodiazepines (25 and 39).
- 公益社団法人日本薬学会の論文
- 1973-11-25
著者
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目黒 寛司
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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多和田 紘之
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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目黒 寛司
浜理薬品工業株式会社
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桑田 胖
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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桑田 胖
Central Research Division, Takeda Chemical Industries, Ltd.
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夏苅 英昭
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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夏苅 英昭
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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多和田 紘之
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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Mizuno K
Faculty Of Integrated Arts And Sciences The University Of Tokushima
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桑田 胖
Central Research Division Takeda Chemical Industries Ltd.
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