Synthesis and Biological Activities of New 1,4-Benzothiazine Derivatives
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概要
- 論文の詳細を見る
New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of tham had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H)-one derivatives 45,74 and 75 showed potent antihypertensive effects.
- 社団法人日本薬学会の論文
- 1991-11-25
著者
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西川 浩平
日本製薬株式会社研究本部
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西川 浩平
Pharamaceutical Research Laboratories I Pharmaceutical Research Division Takeda Chemical Industries
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梶野 正博
Chemistry Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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柴生田 由美子
Biology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.,
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西川 浩平
Biology Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.,
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目黒 寛司
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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水野 克利
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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多和田 紘之
Chemistry Research Laboratories Research and Development Division, Takeda Chemical Industries, Ltd.
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目黒 寛司
浜理薬品工業株式会社
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水野 克利
Chemistry Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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柴生田 由美子
Biology Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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多和田 紘之
Pharmaceutical Research Laboratories Ii Pharmaceutical Research Division Takeda Chemical Industries
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