Synthesis and Biological Activities of Optical Isomers of 2-(4-Diphenylmethyl-1-piperazinyl)ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (Manidipine) Dihydrochloride
スポンサーリンク
概要
- 論文の詳細を見る
Enantiomeric (+)- and (-)-manidipine (1) dihydrochlorides were synthesized by the esterification of the optically active monocarboxylic acids (-)-6 and (+)-6,respectively. The absolute configurations, (S)-(+)-1 and (R)-(-)-1,were unambiguously determined by X-ray crystallographic analysis of (+)-7 derived from (-)-6. The (S)-(+)-1 was about 30 and 80 times as potent as the (R)-(-)-isomer in antihypertensive activity in spontaneously hypertensive rats (SHR), and in the radioligand binding assay using [^3H]nitrendipine, respectively.
- 公益社団法人日本薬学会の論文
- 1989-08-25
著者
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梶野 正博
Chemistry Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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目黒 寛司
浜理薬品工業株式会社
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永井 康雄
Central Research Division Takeda Chemical Industries Ltd.
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目黒 寛司
Central Research Division, Takeda Chemical Industries, Ltd.,
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和田 喜一
Central Research Division, Takeda Chemical Industries, Ltd. Kusunoki-cho, Ikuta-ku, Kobe
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永岡 明伸
Central Research Division, Takeda Chemical Industries, Ltd.
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梶野 正博
Central Research Division, Takeda Chemical Industries, Ltd.,
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永岡 明伸
Central Research Division Takeda Chemical Industries Ltd.
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和田 喜一
Central Research Division Takeda Chemical Industries Ltd.
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