X-Ray Analysis of an Aminoglycoside Antibiotic P-2563 (P) Monohydrobromide
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概要
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The structure of an aminoglycoside antibiotic P-2563 (P) has been confirmed to be 3-O-(4-deoxyl-4-propionamido-α-D-glucopyranosyl)-1,4-diamino-1,4-dideoxyhexytol by the X-ray analysis of its monohydrobromide dihydrate crystals. The pyranose ring is expectedly in a chair form and its substituents are equatorial except that at C (1') which is axial. In the aminopolyol moiety, the arrangements around all of the C-C bonds are in staggered form. The carbon-carbon linkages from C (2) to C (6) are in s-trans zig-zag chain, and the five carbon atoms are almost coplanar. While the C (1) carbon atom is displaced from the plane resulting in the formation of an intramolecular hydrogen bond between the amino groups attached to C (1) and C (4).
- 公益社団法人日本薬学会の論文
- 1978-07-25
著者
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神谷 和秀
Central Research Division Takeda Chemical Industries Ltd.
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和田 喜一
Central Research Division, Takeda Chemical Industries, Ltd. Kusunoki-cho, Ikuta-ku, Kobe
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神谷 和秀
Chemistry Research Laboratories Takeda Chemical Industries Ltd.
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奈良 潔
Central Research Division, Takeda Chemical Industries, Ltd.
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奈良 潔
Central Research Division Takeda Chemical Industries Ltd.
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奈良 潔
Vitamin And Food Research Laboratories Vitamin And Food Division Takeda Chemical Industries Ltd.
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和田 喜一
Central Research Division Takeda Chemical Industries Ltd.
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