44 沢瀉の新トリテルペン化合物
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概要
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The two new triterpenes, named alisol A and alisol B, have been isolated from the rhizomes of Alisma Plantago-aquatica L. var. orientale SAMUELS. (A. orientale JUZEP.), and their structures were elucidated by both chemical and X-ray crystallographic techniques. Alisol A (1) was demonstrated to be a tetracyclic triterpene in which the iso-octyl side chain possesses the glycerol moiety mainly by the chemical evidences that the periodate oxidation of the compound evolved acetone together with the tetranoraldehyde (7), and that acetonization of the compound followed by acetylation afforded the acetonide monoacetate (9). The structure of the ring system was also discussed by physico-chemical measurement. The X-ray analysis on alisol A acetonide monobromoacetate (11) was carried out to establish the structure of alisol A as 1. Alisol B was correlated to alisol A, and was assigned the structure 2. This is the first occurrence of C_<30>-triterpenes having the fusidane-type B/C ring juncture together with a double bond at 13(17) position.
- 1967-09-25
著者
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神谷 和秀
Central Research Division Takeda Chemical Industries Ltd.
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篠原 正和
Central Research Divison Takeda Chemical Industries Ltd.
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西川 正夫
Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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村田 忠一
武田薬品工業株式会社研究開発本部
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村田 忠一
武田薬品化学研究所
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篠原 正和
武田薬品化学研究所
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平田 武夫
武田薬品化学研究所
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西川 正夫
武田薬品化学研究所
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神谷 和秀
武田薬品化学研究所
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宮本 益雄
武田薬品化学研究所
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宮本 益雄
Central Research Divison Takeda Chemical Industries, Ltd.
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西川 正夫
Central Research Division Takeda Chemical Industries Ltd.
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平田 武夫
Research And Development Division Takeda Chemical Industries Ltd.
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宮本 益雄
Central Research Divison Takeda Chemical Industries Ltd.
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