Ubiquinone and Related Compounds. XXVIII. Effect of the Metabolites of α-Tocopherol, Phylloquinone and Ubiquinone on the Stability of Rat-liver Lysosomal Membrane

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• The effect on the stability of rat-liver lysosomal membrane was investigated with trans-2,3,5-trimethyl-6-(5'-carboxy-3'-methyl-2'-pentenyl)-1,4-benzoquinone (E Acid-I), 2,3,5-trimethyl-6-(3'-carboxybutyl)-1,4-benzoquinone (E Acid-II), trans-2-methyl-3-(5'-carboxy-3'-methyl-2'-pentenyl)-1,4-naphthoquinone (K Acid-I), 2-methyl-3-(3'-carboxybutyl)-1,4-naphthoquinone (K Acid-II), trans, cis mixture (3 : 1) of 2,3-dimethoxy-5-methyl-6-(5'-carboxy-3'-methyl-2'-pentenyl)-1,4-benzoquinone (Q Acid-I) and 2,3-dimethoxy-5-methyl-6-(3'-carboxybutyl)-1,4-benzoquinone (Q Acid-II). E Acid-I, E Acid-II, K Acid-I, K Acid-II and Q Acid-I, especially E Acid-I and K Acid-I, inhibited the release of acid phosphatase and β-glucuronidase from the heavy lysosomal fraction of rat-liver in vitro. Q Acid-II accerelated release of the hydrolases. Structure-activity relationships were considered.

• 公益社団法人日本薬学会の論文
• 1974-01-25

著者

• 西川 正夫

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 森本 浩

  Central Reseach Division Takeda Chemical Industries Ltd.

• 西川 正夫

  Central Research Division Takeda Chemical Industries Ltd.

• 今田 伊助

  Central Reseach Division Takeda Chemical Industries Ltd.

• 根岸 良吉

  Chemical Research Laboratories Takeda Chemical Industries Ltd.

• 渡辺 正純

  Central Reseach Division Takeda Chemical Industries Ltd.

• 渡辺 正純

  Chemical Research Laboratories, Takeda Chemical Industries, Ltd.

• 今田 伊助

  Chemical Research Laboratories, Takeda Chemical Industries, Ltd.

• 森本 浩

  Chemical Research Laboratories, Takeda Chemical Industries, Ltd.

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