The Synthesis of N, N'-Disubstituted 2,5-Diamino-6-hydroxy-1,2,3,4-tetrahydro-1-naphthalenol Derivatives

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概要

• 論文の詳細を見る

• In a search for a new type of β-adrenoceptor agonist, a series of N, N'-disubstituted 2,5-diamino-6-hydroxy-1,2,3,4-tetrahydro-1-naphthalenols (2a-q), in which the 5-hydroxyl group of the previously reported rigid catecholamine (1) was replaced by methylamino, dimethylamino, ethylamino, dimethylamino, methanesulfonylamino, ureido, and formamido groups, were synthesized from 6-benzyloxy-5-nitro-4,3-dihydro-1 (2H)-naphthalenone (6). 5-Chloro-2-isopropylamino derivative (53) was also prepared using an intermediate of those syntheses. Biological results for the two derivatives (2d and 2e) are presented.

• 社団法人日本薬学会の論文
• 1977-12-25

著者

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 伊藤 克巳

  Central Research Division, Takeda Chemical Industries, Ltd.,

• 岡 良和

  Central Research Division, Takeda Chemical Industries, Ltd.

• 伊藤 克巳

  武田薬品工業

• 西川 正夫

  Chemical Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 栗木 久

  Central Research Division Takeda Chemical Industries Ltd.

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Central Research Division, Takeda Chemical Industries, Ltd.

• 西川 正夫

  Central Research Division, Takeda Chemical Industries, Ltd.

• 岡 良和

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Central Research Division Takeda Chemical Industries Ltd.

• 西川 正夫

  Central Research Division Takeda Chemical Industries Ltd.

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