Studies on the Syntheses of N-Heterocyclic Compounds. IV. Hypocholesterolemic 1,2,4-Oxadiazole Derivatives. (2)
スポンサーリンク
概要
- 論文の詳細を見る
The derivatives of 3-[4-(1-ethoxycarbonyl-1-methylethoxy) phenyl]-5-(3-pyridyl)-1,2,4-oxadiazole (I), which showed considerable hypocholesterolemic activities, were synthesized. Among them, 3-[4-(1-ethoxycarbonyl-1-methylethoxy) phenyl]-5-(2-or 3-chlorophenyl)-1,2,4-oxadiazole (13,14) and their amide derivatives (29,30) showed nearly equal activity to I. Two alternative synthetic routes of I were developed.
- 1973-09-25
著者
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万木 庄次郎
武田薬品中研
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冨本 光美
京大(医)衛生学
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三宅 昭夫
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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今井 祥雄
Biological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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万木 庄次郎
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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冨本 光美
Chemical Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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松村 晴希
Chemical Research Laboratories Central Research Division, Takeda Chemical Industries, Ltd.
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松村 晴希
Chemical Research Laboratories Central Research Division Takeda Chemical Industries Ltd.
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