含窒素複素環式化合物の合成研究(第19報)4-Alkyl-5,8-disubstituted Amino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazineの合成

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概要

• 論文の詳細を見る

• The reaction of 5,8-dimorpholino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazine (IIa) with equimolar benzyl bromide and sodium hydride afforded 1-benzyl-5,8-dimorpholino-2-phenyl-1,4-dihydropyrimido[4,5-d]pyridazine (IIIa), accompanied by a small amount of 3-benzyl-5,8-dimorpholino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazine (IVa). When IIa was treated with two equimolar benzyl bromide and sodium hydride, 1,4-dibenzyl-5,8-dimorpholino-2-phenyl-1,4-dihydropyrimido[4,5-d]pyridazine (Va) was formed in a good yield, which was converted to 4-benzyl-5,8-dimorpholino-2-phenyl-3,4-dihydropyrimido[4,5-d]pyridazine (VIa), a diuretic agent, by hydrolysis with 10% HCl.

• 公益社団法人日本薬学会の論文
• 1973-08-25

著者

• 伊藤 克己

  Pharmaceutical Research Laboratories Iii Pharmaceutical Research Division Takeda Chemical Industries

• 万木 庄次郎

  武田薬品中研

• 伊藤 克已

  Central Research Division Takeda Chemical Industries Ltd.

• 大村 晴

  Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• 大村 晴

  Medicinal Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 三宅 昭夫

  Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.

• 万木 庄次郎

  武田薬品工業株式会社 研究開発本部 化学研究所

• 伊藤 克己

  武田薬品工業(株)医薬研究本部 医薬品化学第一研究所

• 三宅 昭夫

  武田薬品工業株式会社, 中央研究所, 化学研究所

• 大村 晴

  武田薬品工業株式会社, 中央研究所, 化学研究所

• 大村 晴

  武田薬品工業株式会社

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